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SHR Neuro Cancer Cardio Lipid Metab Microb

Diniz, MS; Hiden, U; Falcao-Pires, I; Oliveira, PJ; Sobrevia, L; Pereira, SP.
Fetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: A potential threat for programming cardiovascular disease
BBA-MOL BASIS DIS. 2023; 1869(8): 166834 Doi: 10.1016/j.bbadis.2023.166834
Web of Science PubMed FullText FullText_MUG

 

Co-authors Med Uni Graz

Hiden Ursula

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Abstract:

Gestational diabetes mellitus (GDM) and maternal obesity (MO) increase the risk of adverse fetal outcomes, and the incidence of cardiovascular disease later in life. Extensive research has been conducted to elucidate the underlying mechanisms by which GDM and MO program the offspring to disease. This review focuses on the role of fetoplacental endothelial dysfunction in programming the offspring for cardiovascular disease in GDM and MO pregnancies. We discuss how pre-existing maternal health conditions can lead to vascular dysfunction in the fetoplacental unit and the fetus. We also examine the role of fetoplacental endothelial dysfunction in impairing fetal cardiovascular system development and the involvement of nitric oxide and hydrogen sulfide in mediating fetoplacental vascular dysfunction. Furthermore, we suggest that the L-Arginine-Nitric Oxide and the AdenosineL-Arginine-Nitric Oxide (ALANO) signaling pathways are pertinent targets for research. Despite significant progress in this area, there are still knowledge gaps that need to be addressed in future research.

Find related publications in this database (Keywords)

Gestational diabesity

Metabolic syndrome

Endothelial dysfunction

Cardiac function

Fetal development

Adenosine receptors

Nitric oxide

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