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SHR Neuro Cancer Cardio Lipid Metab Microb

Jud, P; Hafner, F; Meinitzer, A; Brodmann, M; Dejaco, C; Silbernagel, G.
Cardiovascular diseases and their associations with lipid parameters and endothelial dysfunction in giant cell arteritis.
RMD Open. 2023; 9(3): Doi: 10.1136/rmdopen-2023-003481 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Jud Philipp

Co-authors Med Uni Graz

Brodmann Marianne

Dejaco Christian

Hafner Franz

Meinitzer Andreas

Silbernagel Günther

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Abstract:

OBJECTIVES: Evaluation of endothelial dysfunction, lipid metabolism, prevalence and development of cardiovascular diseases in patients with giant cell arteritis (GCA). METHODS: 138 GCA patients and 100 controls were evaluated for prevalent cardiovascular diseases in 2012. Cholesterol, lipoproteins and triglycerides, intima-media thickness, arterial stiffness, asymmetric and symmetric dimethylarginine were also measured in 2012. Cardiovascular events, mortality and relapse were retrieved by chart review in 2020. RESULTS: Prevalent carotid and vertebral artery disease was higher in GCA patients than in controls (p<0.001). GCA patients had higher levels of total cholesterol, low-density lipoprotein (LDL), intermediate-density lipoprotein, high-density lipoprotein, apolipoprotein A1 and B, and augmentation index (all with p<0.05). Target LDL levels were less frequently achieved at study inclusion by GCA patients (p=0.001), who developed more frequently new cardiovascular events, also with a higher amount, during follow-up (all with p<0.001). Statin treatment in GCA patients was associated with lower levels of asymmetric dimethylarginine, monocytes and C reactive protein (all with p<0.05). Relapse was independently associated with higher risk of future cardiovascular events (OR 5.01 (95% CI 1.55 to 16.22), p=0.007). CONCLUSIONS: GCA patients are at a high risk of developing cardiovascular diseases. Of relevance, there was underuse of statins and a large proportion of these patients showed LDL cholesterol concentrations above the treatment targets for high-risk patients. These data underscore the need for improvement of preventive strategies to reduce cardiovascular risk in GCA patients.

Find related publications in this database (Keywords)

Giant Cell Arteritis

Lipids

Atherosclerosis

Cardiovascular Diseases

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