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Reiter, C; Reiter, G; Kräuter, C; Scherr, D; Schmidt, A; Fuchsjäger, M; Reiter, U.
Evaluation of left ventricular and left atrial volumetric function from native MR multislice 4D flow magnitude data.
Eur Radiol. 2024; 34(2):981-993 Doi: 10.1007/s00330-023-10017-3 [OPEN ACCESS]
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Leading authors Med Uni Graz

Reiter Clemens

Reiter Ursula

Co-authors Med Uni Graz

Fuchsjäger Michael

Kräuter Corina

Reiter Gert

Scherr Daniel

Schmidt Albrecht

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Abstract:

OBJECTIVES: To assess the feasibility, precision, and accuracy of left ventricular (LV) and left atrial (LA) volumetric function evaluation from native magnetic resonance (MR) multislice 4D flow magnitude images. MATERIALS & METHODS: In this prospective study, 60 subjects without signs or symptoms of heart failure underwent 3T native cardiac MR multislice 4D flow and bSSFP-cine realtime imaging. LV and LA volumetric function parameters were evaluated from 4D flow magnitude (4D flow-cine) and bSSFP-cine data using standard software to obtain end-diastolic volume (EDV), end-systolic volume (ESV), ejection-fraction (EF), stroke-volume (SV), LV muscle mass (LVM), LA maximum volume, LA minimum volume, and LA total ejection fraction (LATEF). Stroke volumes derived from both imaging methods were further compared to 4D pulmonary artery flow-derived net forward volumes (NFV). Methods were compared by correlation and Bland-Altman analysis. RESULTS: Volumetric function parameters from 4D flow-cine and bSSFP-cine showed high to very high correlations (r = 0.83-0.98). SV, LA volumes and LATEF did not differ between methods. LV end-diastolic and end-systolic volumes were slightly underestimated (EDV: -2.9 ± 5.8 mL; ESV: -2.3 ± 3.8 mL), EF was slightly overestimated (EF: 0.9 ± 2.6%), and LV mass was considerably overestimated (LVM: 39.0 ± 11.4 g) by 4D flow-cine imaging. SVs from both methods correlated very highly with NFV (r = 0.91 in both cases) and did not differ from NFV. CONCLUSION: Native multislice 4D flow magnitude data allows precise evaluation of LV and LA volumetric parameters; however, apart from SV, LV volumetric parameters demonstrate bias and need to be referred to their respective normal values. CLINICAL RELEVANCE STATEMENT: Volumetric function assessment from native multislice 4D flow magnitude images can be performed with routinely used clinical software, facilitating the application of 4D flow as a one-stop-shop functional cardiac MR exam, providing consistent, simultaneously acquired, volume and flow data. KEY POINTS: • Native multislice 4D flow imaging allows evaluation of volumetric left ventricular and atrial function parameters. • Left ventricular and left atrial function parameters derived from native multislice 4D flow data correlate highly with corresponding standard cine-derived parameters. • Multislice 4D flow-derived volumetric stroke volume and net forward volume do not differ.

Find related publications in this database (using NLM MeSH Indexing)

Humans - administration & dosage

Atrial Function, Left - administration & dosage

Prospective Studies - administration & dosage

Magnetic Resonance Imaging - administration & dosage

Stroke Volume - administration & dosage

Heart Ventricles - diagnostic imaging

Ventricular Function, Left - physiology

Magnetic Resonance Imaging, Cine - methods

Reproducibility of Results - administration & dosage

Find related publications in this database (Keywords)

Magnetic resonance imaging

Cardiovascular system

Diagnostic imaging

Heart function tests

Validation study

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