Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Thompson, GR; Jenks, JD; Baddley, JW; Lewis, JS; Egger, M; Schwartz, IS; Boyer, J; Patterson, TF; Chen, SC; Pappas, PG; Hoenigl, M.
Fungal Endocarditis: Pathophysiology, Epidemiology, Clinical Presentation, Diagnosis, and Management.
Clin Microbiol Rev. 2023; 36(3):e0001923 Doi: 10.1128/cmr.00019-23 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Hönigl Martin

Co-authors Med Uni Graz

Boyer Johannes

Egger Matthias Florian

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Abstract:

Fungal endocarditis accounts for 1% to 3% of all infective endocarditis cases, is associated with high morbidity and mortality (>70%), and presents numerous challenges during clinical care. Candida spp. are the most common causes of fungal endocarditis, implicated in over 50% of cases, followed by Aspergillus and Histoplasma spp. Important risk factors for fungal endocarditis include prosthetic valves, prior heart surgery, and injection drug use. The signs and symptoms of fungal endocarditis are nonspecific, and a high degree of clinical suspicion coupled with the judicious use of diagnostic tests is required for diagnosis. In addition to microbiological diagnostics (e.g., blood culture for Candida spp. or galactomannan testing and PCR for Aspergillus spp.), echocardiography remains critical for evaluation of potential infective endocarditis, although radionuclide imaging modalities such as ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography are increasingly being used. A multimodal treatment approach is necessary: surgery is usually required and should be accompanied by long-term systemic antifungal therapy, such as echinocandin therapy for Candida endocarditis or voriconazole therapy for Aspergillus endocarditis.

Find related publications in this database (using NLM MeSH Indexing)

Humans - administration & dosage

Mycoses - drug therapy

Endocarditis - diagnosis, epidemiology, therapy

Endocarditis, Bacterial - diagnosis

Antifungal Agents - therapeutic use

Candidiasis - diagnosis

Candida - administration & dosage

Aspergillus - administration & dosage

Find related publications in this database (Keywords)

cardiac

diagnosis

endocarditis

endocardium

fungal

mycologic

mycology

treatment

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