Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Gevaert, AB; Wood, N; Boen, JRA; Davos, CH; Hansen, D; Hanssen, H; Krenning, G; Moholdt, T; Osto, E; Paneni, F; Pedretti, RFE; Plösch, T; Simonenko, M; Bowen, TS.
Epigenetics in the primary and secondary prevention of cardiovascular disease: influence of exercise and nutrition.
Eur J Prev Cardiol. 2022; 29(17): 2183-2199. Doi: 10.1093/eurjpc/zwac179
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Co-authors Med Uni Graz

Osto Elena

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Abstract:

Increasing evidence links changes in epigenetic systems, such as DNA methylation, histone modification, and non-coding RNA expression, to the occurrence of cardiovascular disease (CVD). These epigenetic modifications can change genetic function under influence of exogenous stimuli and can be transferred to next generations, providing a potential mechanism for inheritance of behavioural intervention effects. The benefits of exercise and nutritional interventions in the primary and secondary prevention of CVD are well established, but the mechanisms are not completely understood. In this review, we describe the acute and chronic epigenetic effects of physical activity and dietary changes. We propose exercise and nutrition as potential triggers of epigenetic signals, promoting the reshaping of transcriptional programmes with effects on CVD phenotypes. Finally, we highlight recent developments in epigenetic therapeutics with implications for primary and secondary CVD prevention.

Find related publications in this database (using NLM MeSH Indexing)

Humans - administration & dosage

Secondary Prevention - administration & dosage

Cardiovascular Diseases - genetics, prevention & control

Exercise - administration & dosage

Find related publications in this database (Keywords)

DNA methylation

Histone modification

Non-coding RNA

Epigenetic editing

RNA therapeutics

Heart failure

Coronary artery disease

Hypertension

Physical activity

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