Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Guo, J; Qiu, J; Jia, M; Li, Q; Wei, X; Li, L; Pan, Q; Jin, J; Ge, F; Ma, S; He, Y; Lin, J; Li, Y; Ma, J; Jiang, N; Zhi, X; Jiang, L; Zhang, J; Osto, E; Jing, Q; Wang, X; Meng, D.
BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility.
Nucleic Acids Res. 2023; 51(9):4284-4301 Doi: 10.1093/nar/gkad120 [OPEN ACCESS]
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Co-authors Med Uni Graz

Osto Elena

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Abstract:

The transcription factor BTB and CNC homology 1(BACH1) has been linked to coronary artery disease risk by human genome-wide association studies, but little is known about the role of BACH1 in vascular smooth muscle cell (VSMC) phenotype switching and neointima formation following vascular injury. Therefore, this study aims to explore the role of BACH1 in vascular remodeling and its underlying mechanisms. BACH1 was highly expressed in human atherosclerotic plaques and has high transcriptional factor activity in VSMCs of human atherosclerotic arteries. VSMC-specific loss of Bach1 in mice inhibited the transformation of VSMC from contractile to synthetic phenotype and VSMC proliferation and attenuated the neointimal hyperplasia induced by wire injury. Mechanistically, BACH1 suppressed chromatin accessibility at the promoters of VSMC marker genes via recruiting histone methyltransferase G9a and cofactor YAP and maintaining the H3K9me2 state, thereby repressing VSMC marker genes expression in human aortic smooth muscle cells (HASMCs). BACH1-induced repression of VSMC marker genes was abolished by the silencing of G9a or YAP. Thus, these findings demonstrate a crucial regulatory role of BACH1 in VSMC phenotypic transition and vascular homeostasis and shed light on potential future protective vascular disease intervention via manipulation of BACH1.

Find related publications in this database (using NLM MeSH Indexing)

Animals - administration & dosage

Humans - administration & dosage

Mice - administration & dosage

Basic-Leucine Zipper Transcription Factors - deficiency, genetics, metabolism

Chromatin - genetics, metabolism

Homeostasis - administration & dosage

Muscle, Smooth, Vascular - cytology, metabolism

Myocytes, Smooth Muscle - cytology, metabolism

Neointima - genetics, metabolism, pathology, prevention & control

Phenotype - administration & dosage

Plaque, Atherosclerotic - administration & dosage

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