Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

de, Winther, MPJ; Bäck, M; Evans, P; Gomez, D; Goncalves, I; Jørgensen, HF; Koenen, RR; Lutgens, E; Norata, GD; Osto, E; Dib, L; Simons, M; Stellos, K; Ylä-Herttuala, S; Winkels, H; Bochaton-Piallat, ML; Monaco, C.
Translational opportunities of single-cell biology in atherosclerosis.
Eur Heart J. 2023; 44(14): 1216-1230. Doi: 10.1093/eurheartj/ehac686 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Co-authors Med Uni Graz

Osto Elena

Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:

The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell communities that are important in shaping disease development and direct towards new therapeutic strategies. These approaches have begun to revolutionize atherosclerosis pathology and redraw our understanding of disease development. This review discusses the state-of-the-art of single-cell analysis of atherosclerotic plaques, with a particular focus on human lesions, and presents the current resolution of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. Opportunities and pitfalls of current technologies as well as the clinical impact of single-cell technologies in CVD patient care are highlighted, advocating for multidisciplinary and international collaborative efforts to join the cellular dots of CVD.

Find related publications in this database (using NLM MeSH Indexing)

Humans - administration & dosage

Atherosclerosis - pathology

Plaque, Atherosclerotic - pathology

Cardiovascular Diseases - administration & dosage

Find related publications in this database (Keywords)

Single-cell biology

Atherosclerosis

Macrophage

Lymphocyte

Smooth muscle cell

Endothelial cell

© Med Uni Graz • Imprint