Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Patra, V; Bordag, N; Clement, Y; Köfeler, H; Nicolas, JF; Vocanson, M; Ayciriex, S; Wolf, P.
Ultraviolet exposure regulates skin metabolome based on the microbiome.
Sci Rep. 2023; 13(1): 7207 Doi: 10.1038/s41598-023-34073-3 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Patra Vijaykumar

Wolf Peter

Co-authors Med Uni Graz

Bordag Natalie

Köfeler Harald

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Abstract:

Skin metabolites (< 1500 Da) play a critical role in barrier function, hydration, immune response, microbial invasion, and allergen penetration. We aimed to understand the global metabolic profile changes of the skin in relation to the microbiome and UV exposure and exposed germ-free (devoid of microbiome), disinfected mice (partially devoid of skin microbiome) and control mice with intact microbiome to immunosuppressive doses of UVB radiation. Targeted and untargeted lipidome and metabolome profiling was performed with skin tissue by high-resolution mass spectrometry. UV differentially regulated various metabolites such as alanine, choline, glycine, glutamine, and histidine in germ-free mice compared to control mice. Membrane lipid species such as phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were also affected by UV in a microbiome-dependent manner. These results shed light on the dynamics and interactions between the skin metabolome, microbiome, and UV exposure and open new avenues for the development of metabolite- or lipid-based applications to maintain skin health.

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