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SHR Neuro Cancer Cardio Lipid Metab Microb

Shah, S; Mu, C; Moossavi, S; Shen-Tu, G; Schlicht, K; Rohmann, N; Geisler, C; Laudes, M; Franke, A; Züllig, T; Köfeler, H; Shearer, J.
Physical activity-induced alterations of the gut microbiota are BMI dependent.
FASEB J. 2023; 37(4): e22882 Doi: 10.1096/fj.202201571R [OPEN ACCESS]
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Co-authors Med Uni Graz

Köfeler Harald

Züllig Thomas

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Abstract:

Physical inactivity is one of the leading causes of chronic metabolic disease including obesity. Increasing physical activity (PA) has been shown to improve cardiometabolic and musculoskeletal health and to be associated with a distinct gut microbiota composition in trained athletes. However, the impact of PA on the gut microbiota is inconclusive for individuals performing PA in their day-to-day life. This study examined the role of PA and hand-grip strength on gut microbiome composition in middle-aged adults (40-65 years, n = 350) with normal (18.5-24.9 kg/m² ) and overweight (25-29.9 kg/m² ) body mass index (BMI). PA was recorded using the International Physical Activity Questionnaire, and hand-grip strength was measured using a dynamometer. Serum samples were assessed for lipidomics while DNA was extracted from fecal samples for microbiome analysis. Overweight participants showed a higher concentration of triacylglycerols, and lower concentrations of cholesteryl esters, sphingomyelin, and lyso-phosphotidylcholine lipids (p < .05) compared with those with normal BMI. Additionally, overweight participants had a lower abundance of the Oscillibacter genus (p < .05). The impact of PA duration on the gut microbiome was BMI dependent. In normal but not overweight participants, high PA duration showed greater relative abundance of commensal taxa such as Actinobacteria and Proteobacteria phyla, as well as Collinsella and Prevotella genera (p < .05). Furthermore, in males with normal BMI, a stronger grip strength was associated with a higher relative abundance of Faecalibacterium and F. prausnitzii (p < .05) compared with lower grip strength. Taken together, data suggest that BMI plays a significant role in modeling PA-induced changes in gut microbiota.

Find related publications in this database (using NLM MeSH Indexing)

Adult - administration & dosage

Male - administration & dosage

Middle Aged - administration & dosage

Humans - administration & dosage

Gastrointestinal Microbiome - genetics

Body Mass Index - administration & dosage

Obesity - microbiology

Overweight - administration & dosage

Microbiota - administration & dosage

Find related publications in this database (Keywords)

hand-grip strength

lipidomics

microbiome

overweight

physical activity

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