Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Sallmon, H; Delaney, CA.
Platelets and ductus arteriosus closure in neonates.
Semin Perinatol. 2023; 47(2): 151719 Doi: 10.1016/j.semperi.2023.151719
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Sallmon Hannes

Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:

Platelet plug formation is critically involved in murine ductus arteriosus closure and thrombocytopenia in preterm infants seems to negatively affect spontaneous and pharmacologically induced ductal closure. Furthermore, platelet dysfunction may contribute to ductal patency, especially in extremely immature infants. Neonatal platelets likely have multifaceted roles during ductal closure, such as secretion of several signaling molecules and facilitation of specific cell-cell interactions. The only available randomized-controlled trial on platelet transfusions in preterm infants with patent ductus arteriosus demonstrated that a liberal transfusion regimen did not promote ductal closure, but was associated with an increased rate of intraventricular hemorrhage. Herein, we discuss the available mechanistic evidence on the role of platelets in ductus arteriosus closure and their potential clinical implications in preterm infants. We further briefly outline future research directions aimed at a better understanding of platelet-endothelial interactions in neonatal health and disease.

Find related publications in this database (using NLM MeSH Indexing)

Infant - administration & dosage

Infant, Newborn - administration & dosage

Humans - administration & dosage

Animals - administration & dosage

Mice - administration & dosage

Indomethacin - therapeutic use

Cyclooxygenase Inhibitors - therapeutic use

Ibuprofen - therapeutic use

Ductus Arteriosus - administration & dosage

Ductus Arteriosus, Patent - drug therapy

Infant, Extremely Premature - administration & dosage

Find related publications in this database (Keywords)

Preterm infant

Very low birth weight

Patent ductus arteriosus

Platelets

Ibuprofen

Indomethacin

Thrombocytopenia

© Med Uni Graz • Imprint