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SHR Neuro Cancer Cardio Lipid Metab Microb

Zittermann, A; Pilz, S; Morshuis, M; Gummert, F; Milting, H.
Vitamin D deficiency and driveline infection in patients with a left ventricular assist device implant.
Int J Artif Organs. 2023; 46(4):235-240 Doi: 10.1177/03913988231154939
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Co-authors Med Uni Graz

Pilz Stefan

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Abstract:

Driveline infection is a frequent complication in recipients of durable left ventricular assist devices (LVAD), but its cause is largely unclear. Since vitamin D supplementation can reduce the risk of infections, we aimed at investigating the association of vitamin D deficiency with driveline infection. In 154 patients with continuous flow LVAD implants, we assessed 2-year risk of driveline infection according to vitamin D status (circulating 25-hydroxyvitamin D < 25 nmol/L or ⩾25 nmol/L). Of the study cohort, 34% (n = 53) had 25-hydroxyvitamin D concentrations <25 nmol/L. Kaplan-Meir estimates of 2-year freedom from driveline infection were in the vitamin D deficient and vitamin D non-deficient groups 49.7% and 74.2%, respectively (p = 0.017). Covariate-adjusted hazard ratio of driveline infection for the vitamin D deficient versus non-deficient group was 2.51 [95% CI: 1.11-5.69; p = 0.028). Circulating concentrations of endocrine regulators of calcium and phosphorus metabolism such as parathyroid hormone, 1,25-dihydroxyvitamin D, and fibroblast growth factor-23 were not significantly associated with the risk of driveline infection (p-values > 0.15). In total, our data indicate that in LVAD recipients deficient vitamin D status is a predictor of driveline infection, but future studies are needed to investigate whether these associations are causal.

Find related publications in this database (using NLM MeSH Indexing)

Humans - administration & dosage

Heart-Assist Devices - adverse effects

Vitamin D Deficiency - diagnosis, complications

Vitamin D - administration & dosage

Heart Failure - complications

Prosthesis-Related Infections - diagnosis, epidemiology, etiology

Find related publications in this database (Keywords)

Cardiac assist & artificial heart

driveline infection

vitamin D deficiency

infection prevention

morbidity

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