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SHR Neuro Cancer Cardio Lipid Metab Microb

Tona, F; Osto, E; Famoso, G; Previato, M; Fedrigo, M; Vecchiati, A; Perazzolo, Marra, M; Tellatin, S; Bellu, R; Tarantini, G; Feltrin, G; Angelini, A; Thiene, G; Gerosa, G; Iliceto, S.
Coronary microvascular dysfunction correlates with the new onset of cardiac allograft vasculopathy in heart transplant patients with normal coronary angiography.
Am J Transplant. 2015; 15(5):1400-6 Doi: 10.1111/ajt.13108
Web of Science PubMed FullText FullText_MUG

 

Co-authors Med Uni Graz

Osto Elena

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Abstract:

Coronary microvascular dysfunction is emerging as a strong predictor of outcome in heart transplantation (HT). We assessed the validity of microvascular dysfunction, defined by means of a reduced coronary flow reserve (CFR), as a factor associated with new onset epicardial cardiac allograft vasculopathy (CAV) or death. We studied 105 patients at 4 ± 1 years post-HT with a normal coronary angiography (CA). New onset CAV was assessed by CA. CFR was assessed in the left anterior descending (LAD) coronary artery by transthoracic Doppler echocardiography and calculated as the ratio of hyperaemic to basal blood flow velocity. A CFR ≤ 2.5 was considered abnormal. Epicardial CAV onset or death was assessed during a follow-up of 10 years. New onset CAV was diagnosed in 30 patients (28.6%) (Group A), and the CA was normal in the remaining 75 patients (71.4%) (Group B). Group A had reduced CFR compared with group B (2.4 ± 0.6 vs. 3.2 ± 0.7, p < 0.0001). A CFR ≤ 2.5 was independently associated with a higher probability of new onset CAV (p < 0.0001) and a higher probability of death, regardless of CAV onset (p < 0.01). Microvascular dysfunction is independently associated with the onset of epicardial CAV, and associated with a higher risk of death, regardless of CAV onset.

Find related publications in this database (using NLM MeSH Indexing)

Adult - administration & dosage

Aged - administration & dosage

Blood Flow Velocity - administration & dosage

Coronary Angiography - administration & dosage

Coronary Circulation - administration & dosage

Coronary Vessels - diagnostic imaging, pathology

Echocardiography - administration & dosage

Echocardiography, Doppler - administration & dosage

Female - administration & dosage

Graft Rejection - administration & dosage

Heart Rate - administration & dosage

Heart Transplantation - administration & dosage

Humans - administration & dosage

Immunosuppressive Agents - therapeutic use

Kaplan-Meier Estimate - administration & dosage

Male - administration & dosage

Middle Aged - administration & dosage

Prognosis - administration & dosage

Retrospective Studies - administration & dosage

Risk Factors - administration & dosage

Vascular Diseases - pathology

Find related publications in this database (Keywords)

clinical research

practice

heart transplantation

cardiology

heart (allograft) function

dysfunction

vasculopathy

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