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SHR Neuro Cancer Cardio Lipid Metab Microb

Tona, F; Osto, E; Tarantini, G; Gambino, A; Cavallin, F; Feltrin, G; Montisci, R; Caforio, AL; Gerosa, G; Iliceto, S.
Coronary flow reserve by transthoracic echocardiography predicts epicardial intimal thickening in cardiac allograft vasculopathy.
Am J Transplant. 2010; 10(7):1668-76 Doi: 10.1111/j.1600-6143.2010.03160.x
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Leading authors Med Uni Graz

Osto Elena

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Abstract:

Cardiac allograft vasculopathy (CAV) is the leading cause of morbidity and mortality in heart transplantation (HT). We sought to investigate the role of coronary flow reserve (CFR) by contrast-enhanced transthoracic echocardiography (CE-TTE) in CAV diagnosis. CAV was defined as maximal intimal thickness (MIT) assessed by intravascular ultrasound (IVUS) > or =0.5 mm. CFR was assessed in the left anterior descending coronary artery in 22 HT recipients at 6 +/- 4 years post-HT. CAV was diagnosed in 10 patients (group A), 12 had normal coronaries (group B). The mean MIT was 0.7 +/- 0.1 mm (range 0.03-1.8). MIT was higher in group A (1.16 +/- 0.3 mm vs. 0.34 +/- 0.07 mm, p < 0.0001). CFR was 3.1 +/- 0.8 in all patients and lower in group A (2.5 +/- 0.6 vs. 3.7 +/- 0.3, p < 0.0001). CFR was inversely related with MIT (r =-0.774, p < 0.0001). A cut point of < or =2.9, identified as optimal by receiver operating characteristics analysis was 100% specific and 80% sensitive (PPV = 100%, NPV = 89%, Accuracy = 91%). CFR assessment by CE-TTE is a novel noninvasive diagnostic tool in the detection of CAV defined as MIT > or =0.5 mm. CFR by CE-TTE may reduce the need for routine IVUS in HT.

Find related publications in this database (using NLM MeSH Indexing)

Adult - administration & dosage

Blood Flow Velocity - physiology

Coronary Circulation - physiology

Drug Therapy, Combination - administration & dosage

Echocardiography - administration & dosage

Echocardiography, Doppler - methods

Female - administration & dosage

Follow-Up Studies - administration & dosage

Heart Transplantation - diagnostic imaging, immunology, pathology, physiology

Humans - administration & dosage

Immunosuppressive Agents - therapeutic use

Male - administration & dosage

Middle Aged - administration & dosage

Postoperative Complications - epidemiology, mortality

Time Factors - administration & dosage

Tissue Donors - statistics & numerical data

Transplantation, Homologous - pathology

Find related publications in this database (Keywords)

Cardiac allograft vasculopathy

coronary flow reserve

diagnosis

follow-up studies

heart transplantation

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