Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Delli, Gatti, C; Osto, E; Kouroedov, A; Eto, M; Shaw, S; Volpe, M; Lüscher, TF; Cosentino, F.
Pulsatile stretch induces release of angiotensin II and oxidative stress in human endothelial cells: effects of ACE inhibition and AT1 receptor antagonism.
Clin Exp Hypertens. 2008; 30(7):616-27 Doi: 10.1080/10641960802443183
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Leading authors Med Uni Graz

Osto Elena

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Abstract:

Mechanical forces and the activation of the renin-angiotensin system (RAS) may alter the NO/O2(*-) balance, imparing endothelial nitric oxide (NO) availability. This study investigates the link between RAS and NO/O2(*-) balance in human aortic endothelial cells (HAEC) exposed to pulsatile stretch with and without ACE inhibitor quinaprilat or angiotensin II type 1 (AT(1)) receptor antagonist losartan. Pulsatile stretch increased Ang II levels and O2(*-) production, reducing NO release. RAS blockade with quinaprilat or losartan restored the balance between NO and O2(*-). These results provide a molecular basis for understanding the vascular protective effects of ACE inhibition and AT(1) receptor antagonism.

Find related publications in this database (using NLM MeSH Indexing)

Angiotensin II - metabolism

Angiotensin II Type 1 Receptor Blockers - pharmacology

Angiotensin-Converting Enzyme Inhibitors - pharmacology

Biomechanical Phenomena - administration & dosage

Cells, Cultured - administration & dosage

Endothelial Cells - drug effects, metabolism, physiology

Hemorheology - administration & dosage

Humans - administration & dosage

Losartan - pharmacology

Models, Biological - administration & dosage

Nitric Oxide - metabolism

Nitric Oxide Synthase Type III - metabolism

Oxidative Stress - administration & dosage

Pulsatile Flow - administration & dosage

Renin-Angiotensin System - drug effects, physiology

Stress, Mechanical - administration & dosage

Superoxides - metabolism

Tetrahydroisoquinolines - pharmacology

Find related publications in this database (Keywords)

nitric oxide

free radicals

endothelium

renin angiotensin system

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