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SHR Neuro Cancer Cardio Lipid Metab Microb

Haider, A; Bengs, S; Luu, J; Osto, E; Siller-Matula, JM; Muka, T; Gebhard, C.
Sex and gender in cardiovascular medicine: presentation and outcomes of acute coronary syndrome.
Eur Heart J. 2020; 41(13):1328-1336 Doi: 10.1093/eurheartj/ehz898
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Co-authors Med Uni Graz

Osto Elena

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Abstract:

Although health disparities in women presenting with acute coronary syndrome (ACS) have received growing attention in recent years, clinical outcomes from ACS are still worse for women than for men. Women continue to experience higher patient and system delays and receive less aggressive invasive treatment and pharmacotherapies. Gender- and sex-specific variables that contribute to ACS vulnerability remain largely unknown. Notwithstanding the sex differences in baseline coronary anatomy and function, women and men are treated the same based on guidelines that were established from experimental and clinical trial data over-representing the male population. Importantly, younger women have a particularly unfavourable prognosis and a plethora of unanswered questions remains in this younger population. The present review summarizes contemporary evidence for gender and sex differences in vascular biology, clinical presentation, and outcomes of ACS. We further discuss potential mechanisms and non-traditional risk conditions modulating the course of disease in women and men, such as unrecognized psychosocial factors, sex-specific vascular and neural stress responses, and the potential impact of epigenetic modifications.

Find related publications in this database (using NLM MeSH Indexing)

Acute Coronary Syndrome - drug therapy, therapy

Cardiovascular Agents - therapeutic use

Female - administration & dosage

Humans - administration & dosage

Male - administration & dosage

Prognosis - administration & dosage

Risk Factors - administration & dosage

Sex Characteristics - administration & dosage

Sex Factors - administration & dosage

Treatment Outcome - administration & dosage

Find related publications in this database (Keywords)

Acute coronary syndrome

Gender

Sex

Women

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