Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Jud, P; Wimmer, G; Meinitzer, A; Strohmaier, H; Schwantzer, G; Moazedi-Fürst, F; Schweiger, L; Brodmann, M; Hafner, F; Arefnia, B.
Periodontal disease and its association to endothelial dysfunction and clinical changes in limited systemic sclerosis: A case-control study.
J Periodontal Res. 2023; 58(3):621-633 Doi: 10.1111/jre.13111
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Jud Philipp

Co-authors Med Uni Graz

Arefnia Behrouz

Brodmann Marianne

Hafner Franz

Meinitzer Andreas

Moazedi-Fürst Florentine

Schwantzer Gerold

Schweiger Leyla

Strohmaier Heimo

Wimmer Gernot

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Abstract:

OBJECTIVES: Periodontal disease occurs frequently in patients with limited cutaneous systemic sclerosis (lcSSc) while data about underlying pathways contributing to periodontal changes are scarce. The aim of this study was to evaluate periodontal disease and to investigate its association with endothelial dysfunction and clinical changes in patients with lcSSc. METHODS: In 38 lcSSc patients and 38 controls, periodontal status was evaluated by disease-specific questionnaire, dental examination including bleeding on probing (BOP), pocket depth, and plaque index, and dental panoramic radiograph. Periodontopathogen bacteria were collected subgingivally using paper points and interleukin-1 (IL-1) gene polymorphisms were evaluated using buccal swabs. Endothelial dysfunction was measured by flow-mediated dilatation, pulse-wave velocity and biochemical analysis, including arginine metabolites and endothelial microparticles. Additionally, lcSSc-specific clinical changes and parameters were recorded. RESULTS: Periodontitis was present in 31 patients with lcSSc (81.6%) and in 27 controls (71.1%) (p = .280). LcSSc patients had a lower teeth number (p = .039) and Eikenella corrodens was to a higher degree detectable in patients with lcSSc (p = .041) while the remaining periodontal parameters revealed no differences between both cohorts. Significant correlations between parameters of arterial stiffness, EUSTAR index, number of teeth and BOP were observed (all p < .05). Detection of Prevotella intermedia was associated with selected IL-1 gene polymorphisms (p = .032) and Porphyromonas gingivalis was associated with severe periodontitis (p = .041). CONCLUSION: Periodontal disease may occur frequently in patients with lcSSc and may be associated with arterial stiffness and with SSc activity.

Find related publications in this database (Keywords)

arginine metabolism

endothelial dysfunction

endothelial microparticles

periodontal disease

systemic sclerosis

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