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Niemczyk, L; Romejko, K; Szamotulska, K; Schneditz, D; Niemczyk, S.
Changes of Hemodynamic Parameters after Intradialytic Glucose Injection.
Nutrients. 2023; 15(2): Doi: 10.3390/nu15020437 [OPEN ACCESS]
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Co-authors Med Uni Graz

Schneditz Daniel

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Abstract:

BACKGROUND: Intradialytic hypotension (IDH) is a frequent complication of hemodialysis (HD). Current methods of IDH prevention are insufficient. METHODS: We analyzed the intradialytic time course of systolic (SBP), diastolic (DBP), mean arterial (MAP), pulse pressure (PP), and heart rate (HR) in a group of chronic kidney disease (CKD) patients. First, 30 min into HD, a 40% glucose solution was injected into the venous line of the extracorporeal circulation at a dose of 0.5 g/kg of dry weight. Pressures and HR were measured in frequent intervals. Relative volume overload was determined by bioimpedance spectroscopy. RESULTS: Thirty-five participants were studied. SBP increased after 5, 10, and 20 min of glucose infusion. DBP increased after 2 and 3 h and also at the end of HD. PP increased after 5, 10, and 20 min of glucose infusion and fell after the 2nd and 3rd hour and also at the end of HD. MAP increased after 2 and 3 h of glucose injection and at the end of HD. Significant interactions of the time course of SBP, DBP, MAP, with HR at baseline and of the time course of PP with fluid overload were observed. Symptomatic hypotensive episodes were absent. CONCLUSIONS: Glucose infusions during HD prevent symptomatic IDH and do not cause severe hypertensive episodes.

Find related publications in this database (using NLM MeSH Indexing)

Humans - administration & dosage

Kidney Failure, Chronic - complications

Hypotension - etiology, prevention & control

Renal Dialysis - adverse effects

Blood Pressure - administration & dosage

Hypertension - complications

Find related publications in this database (Keywords)

chronic kidney disease

hemodialysis

hypotension

clinical experiment

arterial blood pressure

heart rate

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