Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Tripolt, NJ; Hofer, SJ; Pferschy, PN; Aziz, F; Durand, S; Aprahamian, F; Nirmalathasan, N; Waltenstorfer, M; Eisenberg, T; Obermayer, AMA; Riedl, R; Kojzar, H; Moser, O; Sourij, C; Bugger, H; Oulhaj, A; Pieber, TR; Zanker, M; Kroemer, G; Madeo, F; Sourij, H.
Glucose Metabolism and Metabolomic Changes in Response to Prolonged Fasting in Individuals with Obesity, Type 2 Diabetes and Non-Obese People-A Cohort Trial.
Nutrients. 2023; 15(3): Doi: 10.3390/nu15030511 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Sourij Harald

Tripolt Norbert

Co-authors Med Uni Graz

Aziz Faisal

Bugger Heiko Matthias

Eisenberg Tobias

Kojzar Harald

Moser Othmar

Pferschy Peter

Pieber Thomas

Riedl Regina

Sourij Caren

Zanker Matthias

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Abstract:

Metabolic regulation of glucose can be altered by fasting periods. We examined glucose metabolism and metabolomics profiles after 12 h and 36 h fasting in non-obese and obese participants and people with type 2 diabetes using oral glucose tolerance (OGTT) and intravenous glucose tolerance testing (IVGTT). Insulin sensitivity was estimated by established indices and mass spectrometric metabolomics was performed on fasting serum samples. Participants had a mean age of 43 ± 16 years (62% women). Fasting levels of glucose, insulin and C-peptide were significantly lower in all cohorts after 36 h compared to 12 h fasting (p < 0.05). In non-obese participants, glucose levels were significantly higher after 36 h compared to 12 h fasting at 120 min of OGTT (109 ± 31 mg/dL vs. 79 ± 18 mg/dL; p = 0.001) but insulin levels were lower after 36 h of fasting at 30 min of OGTT (41.2 ± 34.1 mU/L after 36 h vs. 56.1 ± 29.7 mU/L; p < 0.05). In contrast, no significant differences were observed in obese participants or people with diabetes. Insulin sensitivity improved in all cohorts after 36 h fasting. In line, metabolomics revealed subtle baseline differences and an attenuated metabolic response to fasting in obese participants and people with diabetes. Our data demonstrate an improved insulin sensitivity after 36 h of fasting with higher glucose variations and reduced early insulin response in non-obese people only.

Find related publications in this database (Keywords)

metabolic flexibility

obesity

type 2 diabetes

fasting

glucose metabolism

OGTT

IVGTT

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