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SHR Neuro Cancer Cardio Lipid Metab Microb

Klobučar, I; Stadler, JT; Klobučar, L; Lechleitner, M; Trbušić, M; Pregartner, G; Berghold, A; Habisch, H; Madl, T; Marsche, G; Frank, S; Degoricija, V.
Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients.
Int J Mol Sci. 2023; 24(3): Doi: 10.3390/ijms24032073 [OPEN ACCESS]
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Leading authors Med Uni Graz

Frank Sasa

Co-authors Med Uni Graz

Berghold Andrea

Habisch Hansjörg

Lechleitner Margarete

Madl Tobias

Marsche Gunther

Pregartner Gudrun

Stadler Julia

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Abstract:

Metabolic syndrome (MS) is characterized by endothelial- and high-density lipoprotein (HDL) dysfunction and increased endothelial lipase (EL) serum levels. We examined the associations between EL serum levels, HDL (serum levels, lipid content, and function), and endothelial function in healthy volunteers (HV) and MS patients. Flow-mediated dilation (FMD), nitroglycerin-mediated dilation (NMD), serum levels of HDL subclasses (measured by nuclear magnetic resonance (NMR) spectroscopy), and EL serum levels differed significantly between HV and MS patients. The serum levels of triglycerides in large HDL particles were significantly positively correlated with FMD and NMD in HV, but not in MS patients. Cholesterol (C) and phospholipid (PL) contents of large HDL particles, calculated as HDL1-C/HDL1-apoA-I and HDL1-PL/HDL1-apoA-I, respectively, were significantly negatively correlated with FMD in HV, but not in MS patients. Cholesterol efflux capacity and arylesterase activity of HDL, as well as EL, were correlated with neither FMD nor NMD. EL was significantly negatively correlated with HDL-PL/HDL-apoA-I in HV, but not in MS patients, and with serum levels of small dense HDL containing apolipoprotein A-II in MS patients, but not in HV. We conclude that MS modulates the association between HDL and endothelial function, as well as between EL and HDL. HDL cholesterol efflux capacity and arylesterase activity, as well as EL serum levels, are not associated with endothelial function in HV or MS patients.

Find related publications in this database (Keywords)

high-density lipoprotein

endothelial lipase

flow-mediated dilation

NMR spectroscopy

metabolic syndrome

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