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Foris, V; Kovacs, G; Avian, A; Bálint, Z; Douschan, P; Ghanim, B; Klepetko, W; Olschewski, A; Olschewski, H.
Apelin-17 to diagnose idiopathic pulmonary arterial hypertension: A biomarker study.
Front Physiol. 2022; 13: 986295 Doi: 10.3389/fphys.2022.986295 [OPEN ACCESS]
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Leading authors Med Uni Graz

Foris Vasile

Co-authors Med Uni Graz

Avian Alexander

Balint Zoltan

Douschan Philipp

Kovacs Gabor

Olschewski Andrea

Olschewski Horst

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Abstract:

Background: NT-proBNP and GDF-15 are established blood-derived biomarkers for risk assessment in pulmonary hypertension (PH), despite limited sensitivity and specificity. Apelin has a crucial function in endothelial homeostasis, thus it might represent a new biomarker for PH. However, there are numerous circulating apelin isoforms, and their potential role in this setting is unknown. This study evaluated different apelin isoforms in PH patients and prospectively evaluated the role of apelin-17 in comparison with NT-proBNP and GDF-15 as diagnostic marker in idiopathic pulmonary arterial hypertension (IPAH). Methods: Based on our pilot study, we performed a power calculation for apelin-13, apelin-17, apelin-36, as predictor of IPAH vs healthy controls. Apelin-17 provided the best discriminatory power, and accordingly, we enrolled n = 31 patients with IPAH and n = 31 matched healthy controls in a prospective study. NT-proBNP and GDF-15 was determined in all patients. ROC curve analysis was performed to assess the diagnostic value of the markers and their combinations. Results: Apelin-17, NT-proBNP, and GDF-15 were significantly elevated in IPAH patients as compared to controls (p < .001). Apelin-17 detected IPAH with a sensitivity of 68% and a specificity of 93% at a cut-off value of >1,480 pg/ml (AUC 0.86, 95%CI:0.76-0.95) as compared to GDF-15 (sensitivity 86%; specificity 72%, AUC 0.81 (95%CI:0.7-0.92)) and NT-proBNP (sensitivity 86%; specificity 72% (AUC 0.85, 95%CI:0.75-0.95)). Combinations of these markers could be used to increase either specificity or sensitivity. Conclusion: Apelin-17 appears to be suitable blood derived diagnostic marker for idiopathic pulmonary arterial hypertension.

Find related publications in this database (Keywords)

apelin-17

NT-proBNP

GDF-15

blood derived biomarker

diagnosis

idiopathic pulmonary arterial hypertension

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