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Esitgen, Germaner, ET; Wassill, L; Dichtl, K; Roider, J; Seybold, U.
Rapid point of care testing for four bacterial sexually transmitted infections using the portable isothermal loop-mediated nucleic acid amplification eazyplex platform.
Infection. 2023; 51(4):1141-1145 Doi: 10.1007/s15010-023-01981-5 [OPEN ACCESS]
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Co-authors Med Uni Graz

Dichtl Karl

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Abstract:

PURPOSE: To analyze sensitivity and specificity of the rapid point-of-care (POC) eazyplex testing platform for bacterial sexually transmitted infections (STI) among men who have sex with men (MSM). METHODS: 272 anal, urethral, and pharyngeal swabs collected from 153 MSM were tested by both the eazyplex platform and an in-house PCR or culture in the university microbiology reference laboratory. RESULTS: Compared to the reference diagnostic method, the overall sensitivity/specificity of eazyplex was 88%/98% for N. gonorrhoeae, 82%/100% for C. trachomatis, 70%/ > 99% for U. urealyticum, and 85%/98% for M. hominis, respectively. Sensitivity for N. gonorrhoeae and U. urealyticum in urethral samples was 100%. CONCLUSION: With good to very good sensitivity depending on the sampling site and pathogen as well as very good specificity overall the eazyplex platform is a useful rapid diagnostic method for POC bacterial STI-testing especially for N. gonorrhoeae and C. trachomatis, allowing for almost immediate treatment initiation.

Find related publications in this database (using NLM MeSH Indexing)

Male - administration & dosage

Humans - administration & dosage

Homosexuality, Male - administration & dosage

Chlamydia Infections - diagnosis

Sexual and Gender Minorities - administration & dosage

Neisseria gonorrhoeae - genetics

Chlamydia trachomatis - genetics

Point-of-Care Testing - administration & dosage

Gonorrhea - diagnosis, microbiology

Find related publications in this database (Keywords)

Bacterial sexually transmitted infection

Nucleic acid amplification

Point-of-care-test

People living with HIV

Men who have sex with men-MSM

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