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Aschauer, MA; Keeling, IM; Salvan-Schaschl, CV; Knez, I; Binder, B; Raggam, RB; Trantina-Yates, AE.
Gadofosveset-Trinatrium-Enhanced MR Angiography and MR Venography in the Diagnosis of Venous Thromboembolic Disease: A Single-Center Cohort Study
DISEASES-BASEL. 2022; 10(4): 122 Doi: 10.3390/diseases10040122 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Aschauer Manuela

Keeling Ingeborg

Co-authors Med Uni Graz

Binder Barbara

Knez Igor

Raggam Reinhard Bernd

Salvan-Schaschl Carmen-Venetia

Yates Ameli

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Abstract:

Background: The aim of this single-center combined prospective/retrospective cohort study was to analyze Gadolinium (Gd)-enhanced MRA (magnetic resonance angiography) and MRV (MR venography) for the diagnosis of pulmonary artery embolism and deep venous thrombosis. The gold standard methods result in major exposure to radiation and a high amount of nephrotoxic iodinated contrast media. This is the first larger contrast-enhanced MR imaging study of acute and chronic venous thromboembolic disease of various stages. Methods: We prospectively examined 88 patients presenting clinical signs of deep vein thrombosis and/or pulmonary artery embolism. A single-session, one-stop shop Gd-enhanced MRA/MRV at 1.5 Tesla, using gradient echo sequences with very short repetition and echo times as well as low flip angles with subtraction and three-dimensional reconstruction, was performed. A diagnosis was made with the consensus of two experienced radiologists. Results: We observed excellent MRA image quality in 87% and even higher diagnostic image quality of MRV in 90% of our examinations. Pulmonary artery embolism occurred with deep vein thrombosis in 22%. Conclusions: Gd-enhanced MRA/MRV provided excellent image quality for the diagnosis of venous thromboembolic disease in the majority of cases. It may be particularly useful to plan and follow-up filter implantation and retrieval in the inferior caval vein.

Find related publications in this database (Keywords)

magnetic resonance imaging

magnetic resonance angiography

magnetic resonance venography

gadolinium-containing contrast agent

pulmonary artery embolism

deep vein thrombosis

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