Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Obermayer, A; Tripolt, NJ; Pferschy, PN; Kojzar, H; Aziz, F; Müller, A; Schauer, M; Oulhaj, A; Aberer, F; Sourij, C; Habisch, H; Madl, T; Pieber, T; Obermayer-Pietsch, B; Stadlbauer, V; Sourij, H.
Efficacy and Safety of Intermittent Fasting in People With Insulin-Treated Type 2 Diabetes (INTERFAST-2)-A Randomized Controlled Trial.
Diabetes Care. 2023; 46(2):463-468
Doi: 10.2337/dc22-1622
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- Leading authors Med Uni Graz
- Ramirez-Obermayer Anna Maria Antonia
- Sourij Harald
- Co-authors Med Uni Graz
- Aberer Felix
- Aziz Faisal
- Habisch Hansjörg
- Kojzar Harald
- Madl Tobias
- Müller Alexander
- Obermayer-Pietsch Barbara
- Pferschy Peter
- Pieber Thomas
- Schauer Markus
- Sourij Caren
- Stadlbauer-Köllner Vanessa
- Tripolt Norbert
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- Abstract:
- OBJECTIVE: To investigate the safety and feasibility of 3 nonconsecutive days of intermittent fasting (IF) per week over 12 weeks in participants with insulin-treated type 2 diabetes. RESEARCH DESIGN AND METHODS: Forty-six people were randomized to an IF or control group. Dietary counseling and continuous glucose monitoring was provided. Coprimary end points were the change in HbA1c from baseline to 12 weeks and a composite end point (weight reduction ≥2%, insulin dose reduction ≥10%, and HbA1c reduction ≥3 mmol/mol). RESULTS: The IF group showed a significant HbA1c reduction (-7.3 ± 12.0 mmol/mol) compared with the control group (0.1 ± 6.1 mmol/mol) over 12 weeks (P = 0.012). The coprimary end point was achieved by 8 people in the IF and none in the control group (P < 0.001). No severe hypoglycemia occurred. CONCLUSIONS: IF is a safe and feasible dietary option to ameliorate glycemic control while reducing total daily insulin dose and body weight in insulin-treated people with type 2 diabetes.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Blood Glucose - administration & dosage
- Blood Glucose Self-Monitoring - administration & dosage
- Diabetes Mellitus, Type 2 - drug therapy
- Glycated Hemoglobin - administration & dosage
- Hypoglycemic Agents - therapeutic use
- Insulin - therapeutic use
- Intermittent Fasting - administration & dosage