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SHR Neuro Cancer Cardio Lipid Metab Microb

Marttila, S; Tamminen, H; Rajic, S; Mishra, PP; Lehtimaki, T; Raitakari, O; Kahonen, M; Kananen, L; Jylhava, J; Hagg, S; Delerue, T; Peters, A; Waldenberger, M; Kleber, ME; Marz, W; Luoto, R; Raitanen, J; Sillanpaa, E; Laakkonen, EK; Heikkinen, A; Ollikainen, M; Raitoharju, E.
Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues
EPIGENOMICS-UK. 2022; 14(18): 1105-1124. Doi: 10.2217/epi-2022-0228
Web of Science PubMed FullText FullText_MUG

 

Co-authors Med Uni Graz

März Winfried

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Abstract:

Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas similar to 30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues. Tweetable abstract Methylation status of a polymorphically imprinted gene, VTRNA2-1/nc886, is stable in human populations (48 cohorts, n > 30,000) and in somatic tissues, except in cerebellum and skeletal muscle. Twin data suggest it may already be established in the oocyte.

Find related publications in this database (Keywords)

developmental origins of health and disease hypothesis

DNA methylation

imprinting

metastable epiallele

nc886

noncoding 886

polymorphic imprinting

population studies

VTRNA2-1

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