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SHR Neuro Cancer Cardio Lipid Metab Microb

Sinha, M; Zabini, D; Guntur, D; Nagaraj, C; Enyedi, P; Olschewski, H; Kuebler, WM; Olschewski, A.
Chloride channels in the lung: Challenges and perspectives for viral infections, pulmonary arterial hypertension, and cystic fibrosis.
Pharmacol Ther. 2022; 237:108249 Doi: 10.1016/j.pharmthera.2022.108249
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Leading authors Med Uni Graz

Olschewski Andrea

Sinha Madhushri

Co-authors Med Uni Graz

Chandran Nagaraj

Guntur Divya

Olschewski Horst

Zabini-Polzer Diana

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Abstract:

Fine control over chloride homeostasis in the lung is required to maintain membrane excitability, transepithelial transport as well as intra- and extracellular ion and water homeostasis. Over the last decades, a growing number of chloride channels and transporters have been identified in the cells of the pulmonary vasculature and the respiratory tract. The importance of these proteins is underpinned by the fact that impairment of their physiological function is associated with functional dysregulation, structural remodeling, or hereditary diseases of the lung. This paper reviews the field of chloride channels and transporters in the lung and discusses chloride channels in disease processes such as viral infections including SARS-CoV- 2, pulmonary arterial hypertension, cystic fibrosis and asthma. Although chloride channels have become a hot research topic in recent years, remarkably few of them have been targeted by pharmacological agents. As such, we complement the putative pathophysiological role of chloride channels here with a summary of their therapeutic potential.

Find related publications in this database (using NLM MeSH Indexing)

Chloride Channels - metabolism

Chlorides - metabolism

Cystic Fibrosis - drug therapy

Cystic Fibrosis Transmembrane Conductance Regulator - genetics

Familial Primary Pulmonary Hypertension - administration & dosage

Humans - administration & dosage

Lung - metabolism

Pulmonary Arterial Hypertension - administration & dosage

Virus Diseases - drug therapy

Find related publications in this database (Keywords)

Chloride channels

TMEM16

CFTR

Cystic fibrosis

PAH

Viral infection

SARS-CoV-2

Therapeutics

Asthma

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