Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Djalinac, N; Kolesnik, E; Maechler, H; Scheruebel-Posch, S; Pelzmann, B; Rainer, PP; Foessl, I; Wallner, M; Scherr, D; Heinemann, A; Sedej, S; Ljubojevic-Holzer, S; von, Lewinski, D; Bisping, E.
miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium.
Int J Mol Sci. 2022; 23(13):
Doi: 10.3390/ijms23136962
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Dalinac Natasa
- von Lewinski Dirk
- Wallner Markus
- Co-authors Med Uni Graz
- Bisping Egbert Hubertus
- Fößl Ines
- Heinemann Akos
- Holzer Senka
- Kolesnik Ewald
- Mächler Heinrich
- Pelzmann Brigitte
- Rainer Peter
- Scherr Daniel
- Scherübel-Posch Susanne
- Sedej Simon
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Many cardiac insults causing atrial remodeling are linked to either stretch or tachycardia, but a comparative characterization of their effects on early remodeling events in human myocardium is lacking. Here, we applied isometric stretch or sustained tachycardia at 2.5 Hz in human atrial trabeculae for 6 h followed by microarray gene expression profiling. Among largely independent expression patterns, we found a small common fraction with the microRNA miR-1183 as the highest up-regulated transcript (up to 4-fold). Both, acute stretch and tachycardia induced down-regulation of the predicted miR-1183 target genes ADAM20 and PLA2G7. Furthermore, miR-1183 was also significantly up-regulated in chronically remodeled atrial samples from patients with persistent atrial fibrillation (3-fold up-regulation versus sinus rhythm samples), and in ventricular myocardium from dilative cardiomyopathy hearts (2-fold up-regulation) as compared to non-failing controls. In sum, although stretch and tachycardia show distinct transcriptomic signatures in human atrial myocardium, both cardiac insults consistently regulate the expression of miR-1183 and its downstream targets in acute and chronic remodeling. Thus, elevated expression of miR-1183 might serve as a tissue biomarker for atrial remodeling and might be of potential functional significance in cardiac disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Atrial Fibrillation - genetics, metabolism, pathology
- Atrial Remodeling - administration & dosage
- Biomarkers - metabolism
- Humans - administration & dosage
- MicroRNAs - genetics, metabolism
- Myocardium - metabolism
- Tachycardia - genetics, metabolism
- Find related publications in this database (Keywords)
- stretch
- tachycardia
- cardiac remodeling
- microRNA
- MIR1183
- miR-1183
- human myocardium
- biomarker