Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Oflaz, FE; Koshenov, Z; Hirtl, M; Rost, R; Malli, R; Graier, WF.
Sigma-1 Receptor Modulation by Ligands Coordinates Cancer Cell Energy Metabolism.
Biomolecules. 2022; 12(6): Doi: 10.3390/biom12060762 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Graier Wolfgang

Koshenov Zhanat

Oflaz Furkan Enes

Co-authors Med Uni Graz

Hirtl Martin

Malli Roland

Rost René

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Abstract:

Sigma-1 receptor (S1R) is an important endoplasmic reticulum chaperone with various functions in health and disease. The purpose of the current work was to elucidate the involvement of S1R in cancer energy metabolism under its basal, activated, and inactivated states. For this, two cancer cell lines that differentially express S1R were treated with S1R agonist, (+)-SKF10047, and antagonist, BD1047. The effects of the agonist and antagonist on cancer energy metabolism were studied using single-cell fluorescence microscopy analysis of real-time ion and metabolite fluxes. Our experiments revealed that S1R activation by agonist increases mitochondrial bioenergetics of cancer cells while decreasing their reliance on aerobic glycolysis. S1R antagonist did not have a major impact on mitochondrial bioenergetics of tested cell lines but increased aerobic glycolysis of S1R expressing cancer cell line. Our findings suggest that S1R plays an important role in cancer energy metabolism and that S1R ligands can serve as tools to modulate it.

Find related publications in this database (Keywords)

sigma-1 receptor

cancer metabolism

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