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SHR Neuro Cancer Cardio Lipid Metab Microb

Kramer, AM; Kiss, A; Heber, S; Chambers, DJ; Hallström, S; Pilz, PM; Podesser, BK; Santer, D.
Normothermic blood polarizing versus depolarizing cardioplegia in a porcine model of cardiopulmonary bypass.
Interact Cardiovasc Thorac Surg. 2022; 35(1): ivac152 Doi: 10.1093/icvts/ivac152 [OPEN ACCESS]
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Co-authors Med Uni Graz

Hallström Seth

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Abstract:

OBJECTIVES: We have previously demonstrated beneficial cardiac protection with hypothermic polarizing cardioplegia compared to a hyperkalemic depolarizing cardioplegia. In this study, a porcine model of cardiopulmonary bypass was used to compare the protective effects of normothermic blood-based polarizing and depolarizing cardioplegia during cardiac arrest. METHODS: Thirteen pigs were randomized to receive either normothermic polarizing (n = 8) or depolarizing (n = 5) blood-based cardioplegia. After initiation of cardiopulmonary bypass, normothermic arrest (34°C, 60 min) was followed by 60 min of on-pump and 90 min of off-pump reperfusion. Primary outcome was myocardial injury measured as arterial myocardial creatine kinase concentration. Secondary outcome was haemodynamic function and the energy state of the hearts. RESULTS: During reperfusion, release of myocardial creatine kinase was comparable between groups (P = 0.36). In addition, most haemodynamic parameters showed comparable results between groups, but stroke volume (P = 0.03) was significantly lower in the polarizing group. Adenosine triphosphate levels were significantly (18.41 ± 3.86 vs 22.97 ± 2.73 nmol/mg; P = 0.03) lower in polarizing hearts, and the requirement for noradrenaline administration (P = 0.002) and temporary pacing (6 vs 0; P = 0.02) during reperfusion were significantly higher in polarizing hearts. CONCLUSIONS: Under normothermic conditions, polarizing blood cardioplegia was associated with similar myocardial injury to depolarizing blood cardioplegia. Reduced haemodynamic and metabolic outcome and a higher need for temporary pacing with polarized arrest may be associated with the blood-based dilution of this solution.

Find related publications in this database (using NLM MeSH Indexing)

Animals - administration & dosage

Cardioplegic Solutions - pharmacology

Cardiopulmonary Bypass - adverse effects, methods

Creatine Kinase, MB Form - administration & dosage

Heart - administration & dosage

Heart Arrest - administration & dosage

Heart Arrest, Induced - adverse effects, methods

Myocardium - metabolism

Swine - administration & dosage

Find related publications in this database (Keywords)

Cardioplegia

Polarized arrest

Depolarized arrest

Normothermia

Ischaemia-reperfusion

Cardioprotection

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