Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Michel, NA; Ljubojevic-Holzer, S; Bugger, H; Zirlik, A.
Cellular Heterogeneity of the Heart
FRONT CARDIOVASC MED. 2022; 9: 868466 Doi: 10.3389/fcvm.2022.868466 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Anto Michel Nathaly

Zirlik Andreas

Co-authors Med Uni Graz

Bugger Heiko Matthias

Holzer Senka

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Abstract:

Recent advances in technology such as the introduction of high throughput multidimensional tools like single cell sequencing help to characterize the cellular composition of the human heart. The diversity of cell types that has been uncovered by such approaches is by far greater than ever expected before. Accurate identification of the cellular variety and dynamics will not only facilitate a much deeper understanding of cardiac physiology but also provide important insights into mechanisms underlying its pathological transformation. Distinct cellular patterns of cardiac cell clusters may allow differentiation between a healthy heart and a sick heart while potentially predicting future disease at much earlier stages than currently possible. These advances have already extensively improved and will ultimately revolutionize our knowledge of the mechanisms underlying cardiovascular disease as such. In this review, we will provide an overview of the cells present in the human and rodent heart as well as genes that may be used for their identification.

Find related publications in this database (Keywords)

single cell RNA sequencing

heart

cell type

heterogeneity

genes

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