Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Niestrawska, JA; Pukaluk, A; Babu, AR; Holzapfel, GA.
Differences in Collagen Fiber Diameter and Waviness between Healthy and Aneurysmal Abdominal Aortas.
Microsc Microanal. 2022; 1-15 Doi: 10.1017/S1431927622000629
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Niestrawska Justyna Anna

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Abstract:

Collagen plays a key role in the strength of aortic walls, so studying micro-structural changes during disease development is critical to better understand collagen reorganization. Second-harmonic generation microscopy is used to obtain images of human aortic collagen in both healthy and diseased states. Methods are being developed in order to efficiently determine the waviness, that is, tortuosity and amplitude, as well as the diameter, orientation, and dispersion of collagen fibers, and bundles in healthy and aneurysmal tissues. The results show layer-specific differences in the collagen of healthy tissues, which decrease in samples of aneurysmal aortic walls. In healthy tissues, the thick collagen bundles of the adventitia are characterized by greater waviness, both in the tortuosity and in the amplitude, compared to the relatively thin and straighter collagen fibers of the media. In contrast, most aneurysmal tissues tend to have a more uniform structure of the aortic wall with no significant difference in collagen diameter between the luminal and abluminal layers. An increase in collagen tortuosity compared to the healthy media is also observed in the aneurysmal luminal layer. The data set provided can help improve related material and multiscale models of aortic walls and aneurysm formation.

Find related publications in this database (Keywords)

aneurysm

collagen fibers

diameter

human abdominal aorta

second-harmonic generation microscopy

waviness

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