Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Eckstein, ML; Brockfeld, A; Haupt, S; Schierbauer, JR; Zimmer, RT; Wachsmuth, N; Zunner, B; Zimmermann, P; Obermayer-Pietsch, B; Moser, O.
Acute Metabolic Responses to Glucose and Fructose Supplementation in Healthy Individuals: A Double-Blind Randomized Crossover Placebo-Controlled Trial
NUTRIENTS. 2021; 13(11): 4095 Doi: 10.3390/nu13114095 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Eckstein Max Lennart

Moser Othmar

Co-authors Med Uni Graz

Obermayer-Pietsch Barbara

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Abstract:

The aim of this study was to investigate the impact of glucose (Glu), fructose (Fru), glucose and fructose (GluFru) and sucralose on blood glucose response in healthy individuals. Fifteen healthy individuals (five females, age of 25.4 & PLUSMN; 2.5 years, BMI of 23.7 & PLUSMN; 1.7 kg/m(2) with a body mass (BM) of 76.3 & PLUSMN; 12.3 kg) participated in this double-blind randomized crossover placebo-controlled trial. Participants received a mixture of 300 mL of water with 1 g/kg BM of Glu, 1 g/kg BM of Fru, 0.5 g/kg BM of GluFru (each), and 0.2 g sucralose as a placebo. Peak BG values Glu were reached after 40 & PLUSMN; 13 min (peak BG: 141 & PLUSMN; 20 mg/dL), for Fru after 36 & PLUSMN; 22 min (peak BG: 98 & PLUSMN; 7 mg/dL), for GluFru after 29 & PLUSMN; 8 min (BG 128 & PLUSMN; 18 mg/dL), and sucralose after 34 & PLUSMN; 27 min (peak BG: 83 & PLUSMN; 5 mg/dL). Significant differences regarding the time until peak BG were found only between Glu and GluFru supplementation (p = 0.02). Peak blood glucose levels were significantly lower following the ingestion of Fru compared to the supplementation of Glu and GluFru (p < 0.0001) while Glu and GluFru supplementation showed no difference in peak values (p = 0.23). All conditions led to a significantly higher peak BG value compared to sucralose (p < 0.0001). Blood lactate increased in Glu (p = 0.002), Fru and GluFru (both p < 0.0001), whereas sucralose did not increase compared to the baseline (p = 0.051). Insulin levels were significantly higher in all conditions at peak compared to sucralose (p < 0.0001). The findings of this study prove the feasibility of combined carbohydrate supplementations for many applications in diabetic or healthy exercise cohorts.

Find related publications in this database (Keywords)

glucose

metabolism

fructose

sucralose

healthy individuals

insulin

substrate oxidation

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