Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Lindenmann, J; Smolle, C; Kamolz, LP; Smolle-Juettner, FM; Graier, WF.
Survey of Molecular Mechanisms of Hyperbaric Oxygen in Tissue Repair.
Int J Mol Sci. 2021; 22(21): Doi: 10.3390/ijms222111754 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Lindenmann Jörg

Smolle Christian

Co-authors Med Uni Graz

Graier Wolfgang

Kamolz Lars-Peter

Smolle-Juettner Freyja-Maria

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Abstract:

For more than six decades, hyperbaric oxygen (HBO) has been used for a variety of indications involving tissue repair. These indications comprise a wide range of diseases ranging from intoxications to ischemia-reperfusion injury, crush syndrome, central nervous injury, radiation-induced tissue damage, burn injury and chronic wounds. In a systematic review, the molecular mechanisms triggered by HBO described within the last two decades were compiled. They cover a wide range of pathways, including transcription, cell-to-cell contacts, structure, adhesion and transmigration, vascular signaling and response to oxidative stress, apoptosis, autophagy and cell death, as well as inflammatory processes. By analyzing 71 predominantly experimental publications, we established an overview of the current concepts regarding the molecular mechanisms underlying the effects of HBO. We considered both the abovementioned pathways and their role in various applications and indications.

Find related publications in this database (Keywords)

hyperbaric oxygenation (HBO)

reactive oxygen species (ROS)

oxidative stress

tissue repair

molecular mechanism

transcription

vascular signaling

inflammation

cell structure

cell death

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