Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Alhamdan, F; Marsh, LM; Pedersen, F; Alhamwe, BA; Thölken, C; Pfefferle, PI; Bahmer, T; Greulich, T; Potaczek, DP; Garn, H.
Differential Regulation of Interferon Signaling Pathways in CD4⁺ T Cells of the Low Type-2 Obesity-Associated Asthma Phenotype.
Int J Mol Sci. 2021; 22(18): Doi: 10.3390/ijms221810144 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Co-authors Med Uni Graz

Marsh Leigh

Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:

In the era of personalized medicine, insights into the molecular mechanisms that differentially contribute to disease phenotypes, such as asthma phenotypes including obesity-associated asthma, are urgently needed. Peripheral blood was drawn from 10 obese, non-atopic asthmatic adults with a high body mass index (BMI; 36.67 ± 6.90); 10 non-obese, non-atopic asthmatic adults with normal BMI (23.88 ± 2.73); and 10 healthy controls with normal BMI (23.62 ± 3.74). All asthmatic patients were considered to represent a low type-2 asthma phenotype according to selective clinical parameters. RNA sequencing (RNA-Seq) was conducted on peripheral blood CD4⁺ T cells. Thousands of differentially expressed genes were identified in both asthma groups compared with heathy controls. The expression of interferon (IFN)-stimulated genes associated with IFN-related signaling pathways was specifically affected in obese asthmatics, while the gap junction and G protein-coupled receptor (GPCR) ligand binding pathways were enriched in both asthma groups. Furthermore, obesity gene markers were also upregulated in CD4⁺ T cells from obese asthmatics compared with the two other groups. Additionally, the enriched genes of the three abovementioned pathways showed a unique correlation pattern with various laboratory and clinical parameters. The specific activation of IFN-related signaling and viral infection pathways might provide a novel view of the molecular mechanisms associated with the development of the low type-2 obesity-associated asthma phenotype, which is a step ahead in the development of new stratified therapeutic approaches.

Find related publications in this database (using NLM MeSH Indexing)

Adult - administration & dosage

Asthma - complications, metabolism

CD4-Positive T-Lymphocytes - metabolism

Cells, Cultured - administration & dosage

Female - administration & dosage

Humans - administration & dosage

Interferons - metabolism

Male - administration & dosage

Middle Aged - administration & dosage

Obesity - complications, metabolism

Receptors, G-Protein-Coupled - metabolism

Signal Transduction - administration & dosage

Find related publications in this database (Keywords)

low type-2 asthma

obesity

asthma phenotypes

CD4(+) T cells

transcriptomics

© Med Uni Graz • Imprint