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SHR Neuro Cancer Cardio Lipid Metab Microb

Khuseyinova, N; Imhof, A; Rothenbacher, D; Trischler, G; Kuelb, S; Scharnagl, H; Maerz, W; Brenner, H; Koenig, W.
Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis.
ATHEROSCLEROSIS. 2005; 182(1): 181-188. Doi: 10.1016/j.atherosclerosis.2004.10.046
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Co-authors Med Uni Graz

März Winfried

Scharnagl Hubert

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Abstract:

Lipoprotein-associated phospholipase A2 (Lp-PLA2) generates pro-inflammatory molecules from oxidized LDL. We examined the association between Lp-PLA2 plasma concentrations and risk of stable coronary artery disease (CAD) in a large case-control study and further assessed the relationship between Lp-PLA2 and various lipid, inflammatory and hemostatic parameters. Lp-PLA2 concentrations were measured in 312 patients with CAD and in 479 age- and gender-matched blood donors. Various sensitive inflammatory and hemostatic markers and a complete lipoprotein profile were obtained. Lp-PLA2 concentrations were significantly higher in cases than in controls (296.1 ng/mL versus 266.0 ng/mL, p<0.0001). In multivariable logistic regression, the age- and gender-adjusted OR for the presence of CAD was 1.61 (95% CI, 1.07-2.44) if the top quartile of the Lp-PLA2 distribution was compared to the bottom quartile. Adjustment for traditional cardiovascular risk factors and statin use resulted in an OR of 2.04 (95% CI, 1.19-3.48). After additional controlling for vWF, the OR was slightly attenuated but still remained statistically significant (OR 1.91; 95% CI, 1.12-3.28). Thus, elevated Lp-PLA2 concentrations were associated with the presence of stable CAD, independent of various biochemical markers. Our results support the hypothesis that Lp-PLA2 may be a novel, independent risk marker for CAD.

Find related publications in this database (using NLM MeSH Indexing)

Aged -

Biological Markers - blood

Case-Control Studies - blood

Coronary Arteriosclerosis - blood

Female - blood

Hemostasis - immunology

Humans - immunology

Lipoproteins - blood

Male - blood

Middle Aged - blood

Phospholipases A - blood

Risk Factors - blood

Severity of Illness Index - blood

Find related publications in this database (Keywords)

coronary artery disease

Lp-PLA(2)

lipoproteins

inflammation

risk factors

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