Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Gibb, AA; Murray, EK; Eaton, DM; Huynh, AT; Tomar, D; Garbincius, JF; Kolmetzky, DW; Berretta, RM; Wallner, M; Houser, SR; Elrod, JW.
Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model.
JACC Basic Transl Sci. 2021; 6(8):650-672 Doi: 10.1016/j.jacbts.2021.07.004 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Co-authors Med Uni Graz

Wallner Markus

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Abstract:

In this study the authors used systems biology to define progressive changes in metabolism and transcription in a large animal model of heart failure with preserved ejection fraction (HFpEF). Transcriptomic analysis of cardiac tissue, 1-month post-banding, revealed loss of electron transport chain components, and this was supported by changes in metabolism and mitochondrial function, altogether signifying alterations in oxidative metabolism. Established HFpEF, 4 months post-banding, resulted in changes in intermediary metabolism with normalized mitochondrial function. Mitochondrial dysfunction and energetic deficiencies were noted in skeletal muscle at early and late phases of disease, suggesting cardiac-derived signaling contributes to peripheral tissue maladaptation in HFpEF. Collectively, these results provide insights into the cellular biology underlying HFpEF progression.

Find related publications in this database (Keywords)

heart failure

mitochondria

metabolomics

preserved ejection fraction

systems biology

transcriptomics

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