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SHR Neuro Cancer Cardio Lipid Metab Microb

Kempf, K; Röhling, M; Banzer, W; Braumann, KM; Halle, M; McCarthy, D; Predel, HG; Schenkenberger, I; Tan, S; Toplak, H; Berg, A; Martin, S; On, Behalf, Of, Acoorh, Study, Group.
High-Protein, Low-Glycaemic Meal Replacement Decreases Fasting Insulin and Inflammation Markers-A 12-Month Subanalysis of the ACOORH Trial.
NUTRIENTS. 2021; 13(5): Doi: 10.3390/nu13051433 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Co-authors Med Uni Graz

Toplak Hermann

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Abstract:

Lifestyle interventions, including meal replacement, are effective in the prevention and treatment of type-2-diabetes and obesity. Since insulin is the key weight regulator, we hypothesised that the addition of meal replacement to a lifestyle intervention reduces insulin levels more effectively than lifestyle intervention alone. In the international multicentre randomised controlled ACOORH (Almased Concept against Overweight and Obesity and Related Health Risk) trial, overweight or obese persons who meet the criteria for metabolic syndrome (n = 463) were randomised into two groups. Both groups received nutritional advice focusing on carbohydrate restriction and the use of telemonitoring devices. The intervention group substituted all three main meals per day in week 1, two meals per day in weeks 2-4, and one meal per day in weeks 5-26 with a protein-rich, low-glycaemic meal replacement. Data were collected at baseline and after 1, 3, 6 and 12 months. All datasets providing insulin data (n = 446) were included in this predefined subanalysis. Significantly higher reductions in insulin (-3.3 ± 8.7 µU/mL vs. -1.6 ± 9.8 µU/mL), weight (-6.1 ± 5.2 kg vs. -3.2 ± 4.6 kg), and inflammation markers were observed in the intervention group. Insulin reduction correlated with weight reduction and the highest amount of weight loss (-7.6 ± 4.9 kg) was observed in those participants with an insulin decrease > 2 µU/mL. These results underline the potential for meal replacement-based lifestyle interventions in diabetes prevention, and measurement of insulin levels may serve as an indicator for adherence to carbohydrate restriction.

Find related publications in this database (using NLM MeSH Indexing)

Adult - administration & dosage

Aged - administration & dosage

Biomarkers - administration & dosage

Body Weight - administration & dosage

Chronic Disease - administration & dosage

Dietary Proteins - pharmacology

Fasting - blood

Female - administration & dosage

Glycemic Index - drug effects

Humans - administration & dosage

Inflammation - blood, pathology

Insulin - blood

Intention to Treat Analysis - administration & dosage

Male - administration & dosage

Meals - administration & dosage

Middle Aged - administration & dosage

Patient Dropouts - administration & dosage

Young Adult - administration & dosage

Find related publications in this database (Keywords)

fasting insulin

lifestyle intervention

protein-rich

low-glycaemic meal replacement

low-carbohydrate

overweight

obesity

weight reduction

multicentre study

RCT

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