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Niemczyk, L; Schneditz, D; Wojtecka, A; Szamotulska, K; Smoszna, J; Niemczyk, S.
Glucose tolerance in patients with and without type 2 diabetes mellitus during hemodialysis.
Diabetes Res Clin Pract. 2021; 173:108694-108694 Doi: 10.1016/j.diabres.2021.108694 [OPEN ACCESS]
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Schneditz Daniel

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Abstract:

The disposal of a glucose bolus was studied to identify glucose metabolism in patients with and without type 2 diabetes mellitus (T2DM) during their regular hemodialysis (HD) treatment. Plasma glucose, insulin, and c-peptide concentrations were measured during a 60 min observation phase following a rapid glucose infusion (0.5 g/kg dry weight). Glucose disposition and elimination rates were determined from kinetic analysis, and insulinogenic index was calculated. Insulin resistance (R_HOMA) was determined by homeostatic model assessment (HOMA). 35 HD patients (14 with T2DM) distinguished by a higher age (median: 70 vs. 55 y, p < 0.01) in T2DM patients were studied. Glucose kinetic data showed only small differences between patients with or without T2DM, but as R_HOMA measured in all patients increased, a larger fraction of glucose was removed by the extracorporeal system (r = 0.430, p = 0.01). One hour after glucose bolus injection the glucose level was not different from that before HD also in patients with T2DM (p = 0.115). The larger glucose amount recovered in dialysate in patients with increasing R_HOMA indicates that impaired glucose disposal could be measured during HD using a non-invasive dialysis quantification approach without blood sampling. Glucose infusion during HD is safe also in patients with T2DM. Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Find related publications in this database (using NLM MeSH Indexing)

Aged -

Blood Glucose - metabolism

Diabetes Mellitus, Type 2 - blood

Female -

Humans -

Male -

Middle Aged -

Renal Dialysis - methods

Find related publications in this database (Keywords)

Hemodialysis

Glucose

Kinetics

Clearance

Insulin resistance

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