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SHR Neuro Cancer Cardio Lipid Metab Microb

Moser, O; Tripolt, N; Pferschy, P; Obermayer, A; Kojzar, H; Mueller, A; Yildirim, H; Sourij, C; Eckstein, M; Sourij, H.
Performance of the Intermittently Scanned Continuous Glucose Monitoring (isCGM) System during a High Oral Glucose Challenge in Adults with Type 1 Diabetes-A Prospective Secondary Outcome Analysis.
BIOSENSORS-BASEL. 2021; 11(1): Doi: 10.3390/bios11010022 [OPEN ACCESS]
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Leading authors Med Uni Graz

Moser Othmar

Co-authors Med Uni Graz

Eckstein Max Lennart

Kojzar Harald

Müller Alexander

Pferschy Peter

Ramirez-Obermayer Anna Maria Antonia

Sourij Caren

Sourij Harald

Tripolt Norbert

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Abstract:

To assess intermittently scanned continuous glucose monitoring (isCGM) performance for different rates of change in plasma glucose (RCPG) during glycemic challenges in type 1 diabetes (T1D). Nineteen people with T1D (7 females; age 35 ± 11 years; HbA_1c 7.3 ± 0.6% (56 ± 7 mmol/mol)) performing two glycemic challenges (OGTT) were included. During OGTTs, plasma glucose was compared against sensor glucose for timepoints 0 min (pre-OGTT), +15 min, +30 min, +60 min, +120 min, +180 min, and +240 min by means of median absolute (relative) difference (MARD and MAD) and Clarke Error Grid (CEG), then was stratified for RCPG and glycemic ranges. Overall, MARD was 8.3% (4.0-14.8) during hypoglycemia level 1 18.8% (15.8-22.0), euglycemia 9.5% (4.3-15.1), hyperglycemia level 1 9.4% (4.0-17.2), and hyperglycemia level 2 7.1% (3.3-11.9). The MARD was associated with the RCPG (p < 0.0001), detailing significant differences in comparison of low, moderate, high, and very high RCPG (p = 0.014). Overall, CEG resulted in 88% (212 values) of comparison points in zone A, 12% (29 values) in zone B, and 0.4% (1 value) in zone D. The isCGM system was accurate during OGTTs. Its performance was dependent on the RCPG and showed an overestimation of the actual reference glucose during hypoglycemia.

Find related publications in this database (Keywords)

isCGM

glycemia

accuracy

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