Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Rupp, J; Dreo, B; Gütl, K; Fessler, J; Moser, A; Haditsch, B; Schilcher, G; Matzkies, LM; Steinmetz, I; Greinix, H; Stradner, MH.
T Cell Phenotyping in Individuals Hospitalized with COVID-19.
J Immunol. 2021; 206(7):1478-1482 Doi: 10.4049/jimmunol.2001034
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Rupp Janine

Stradner Martin Helmut

Co-authors Med Uni Graz

Dreo Barbara

Fessler Johannes

Greinix Hildegard

Kurzmann-Gütl Katharina

Matzkies Lucie-Marie

Moser Adrian

Schilcher Gernot

Steinmetz Ivo

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Abstract:

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become pandemic. Cytokine release syndrome occurring in a minority of SARS-CoV-2 infections is associated with severe disease and high mortality. We profiled the composition, activation, and proliferation of T cells in 20 patients with severe or critical COVID-19 and 40 matched healthy controls by flow cytometry. Unsupervised hierarchical cluster analysis based on 18 T cell subsets resulted in separation of healthy controls and COVID-19 patients. Compared to healthy controls, patients suffering from severe and critical COVID-19 had increased frequencies of activated and proliferating CD38⁺Ki67⁺ CD4⁺ and CD8⁺ T cells, suggesting active antiviral T cell defense. Frequencies of CD38⁺Ki67⁺ Th1 and CD4⁺ cells correlated negatively with plasma IL-6. Thus, our data suggest that patients suffering from COVID-19 have a distinct T cell composition that is potentially modulated by IL-6. Copyright © 2021 by The American Association of Immunologists, Inc.

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