Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Wunsch, S; Zurl, C; Strohmaier, H; Meinitzer, A; Rabensteiner, J; Posch, W; Lass-Flörl, C; Cornely, O; Pregartner, G; König, E; Feierl, G; Hoenigl, M; Prattes, J; Zollner-Schwetz, I; Valentin, T; Krause, R.
Longitudinal Evaluation of Plasma Cytokine Levels in Patients with Invasive Candidiasis.
J Fungi (Basel). 2021; 7(2): Doi: 10.3390/jof7020101 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Krause Robert

Wunsch Stefanie

Co-authors Med Uni Graz

Feierl Gebhard

Hönigl Martin

König Elisabeth

Meinitzer Andreas

Prattes Jürgen

Pregartner Gudrun

Rabensteiner Jasmin

Strohmaier Heimo

Valentin Thomas

Zollner-Schwetz Ines

Zurl Christoph Johann

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Abstract:

Interleukin (IL) 17A plays a decisive role in anti-Candida host defense. Previous data demonstrated significantly increased IL-17A values in candidemic patients. We evaluated levels and time courses of IL-17A, and other cytokines suggested to be involved in Candida-specific immunity (IL-6, IL-8, IL-10, IL-17F, IL-22, IL-23, interferon-γ, tumor necrosis factor-α, Pentraxin-related protein 3, transforming growth factor-β) in patients with invasive candidiasis (IC) compared to bacteremic patients (Staphylococcus aureus, Escherichia coli) and healthy controls (from previous 4 days up to day 14 relative to the index culture (-4; 14)). IL-17A levels were significantly elevated in all groups compared to healthy controls. In IC, the highest IL-17A values were measured around the date of index sampling (-1; 2), compared to significantly lower levels prior and after sampling the index culture. Candidemic patients showed significantly higher IL-17A values compared to IC other than candidemia at time interval (-1; 2) and (3; 7). No significant differences in IL-17A levels could be observed for IC compared to bacteremic patients. Candidemic patients had higher IL-8, IL-10, IL-22, IFN-γ, PTX3 and TNF-α values compared to non-candidemic. Based on the limited discriminating competence between candidemia and bacteremia, IL-17A has to be considered a biomarker for blood stream infection rather than invasive Candida infection.

Find related publications in this database (Keywords)

interleukin 17A

interleukins

cytokines

biomarker

Candida

invasive candidiasis

candidemia

tryptophan-kynurenine metabolism

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