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SHR Neuro Cancer Cardio Lipid Metab Microb

Maric, J; Ravindran, A; Mazzurana, L; Björklund, ÅK; Van Acker, A; Rao, A; Friberg, D; Dahlén, SE; Heinemann, A; Konya, V; Mjösberg, J.
Prostaglandin E₂ suppresses human group 2 innate lymphoid cell function.
J Allergy Clin Immunol. 2018; 141(5):1761-1773 Doi: 10.1016/j.jaci.2017.09.050 [OPEN ACCESS]
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Leading authors Med Uni Graz

Konya Viktoria

Maric Jovana

Co-authors Med Uni Graz

Heinemann Akos

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Abstract:

Group 2 innate lymphoid cells (ILC2s) are involved in the initial phase of type 2 inflammation and can amplify allergic immune responses by orchestrating other type 2 immune cells. Prostaglandin (PG) E₂ is a bioactive lipid that plays protective roles in the lung, particularly during allergic inflammation. We set out to investigate how PGE₂ regulates human ILC2 function. The effects of PGE₂ on human ILC2 proliferation and intracellular cytokine and transcription factor expression were assessed by means of flow cytometry. Cytokine production was measured by using ELISA, and real-time quantitative PCR was performed to detect PGE₂ receptor expression. PGE₂ inhibited GATA-3 expression, as well as production of the type 2 cytokines IL-5 and IL-13, from human tonsillar and blood ILC2s in response to stimulation with a combination of IL-25, IL-33, thymic stromal lymphopoietin, and IL-2. Furthermore, PGE₂ downregulated the expression of IL-2 receptor α (CD25). In line with this observation, PGE₂ decreased ILC2 proliferation. These effects were mediated by the combined action of E-type prostanoid receptor (EP) 2 and EP4 receptors, which were specifically expressed on ILC2s. Our findings reveal that PGE₂ limits ILC2 activation and propose that selective EP2 and EP4 receptor agonists might serve as a promising therapeutic approach in treating allergic diseases by suppressing ILC2 function. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Find related publications in this database (using NLM MeSH Indexing)

Cells, Cultured -

Cytokines - immunology

Dinoprostone - immunology

GATA3 Transcription Factor - immunology

Gene Expression Regulation - immunology

Humans -

Immunity, Innate - immunology

Inflammation - immunology

Lymphocytes - immunology

Receptors, Prostaglandin E - immunology

Find related publications in this database (Keywords)

ILC2

allergy

prostaglandin E-2

E-type prostanoid receptor 2

E-type prostanoid receptor 4

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