Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Trauner, M; Halilbasic, E; Claudel, T; Steinacher, D; Fuchs, C; Moustafa, T; Pollheimer, M; Krones, E; Kienbacher, C; Traussnigg, S; Kazemi-Shirazi, L; Munda, P; Hofer, H; Fickert, P; Paumgartner, G.
Potential of nor-Ursodeoxycholic Acid in Cholestatic and Metabolic Disorders.
Dig Dis. 2015; 33(3):433-439 Doi: 10.1159/000371904
Web of Science PubMed FullText FullText_MUG

 

Leading authors Med Uni Graz

Trauner Michael

Co-authors Med Uni Graz

Claudel Thierry

Fickert Peter

Fuchs Claudia

Halilbasic Emina

Hofer Herwig

Moustafa Tarek

Pollheimer Marion

Tatscher Elisabeth

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Abstract:

24-nor-ursodeoxycholic acid (norUDCA) is a side-chain shortened derivate of ursodeoxycholic acid (UDCA). Since norUDCA is only ineffectively conjugated with glycine or taurine, it has specific physicochemical and therapeutic properties distinct from UDCA. Nonamidated norUDCA undergoes cholehepatic shunting enabling 'ductular targeting' and inducing a bicarbonate-rich hypercholeresis, with cholangioprotective effects. At the same time it has direct anti-inflammatory, antilipotoxic, anti fibrotic, and antiproliferative properties targeting various liver cell populations. norUDCA appears to be one of the most promising novel treatment approaches targeting the liver and the bile duct system at multifactorial and multicellular levels. This review article is a summary of a lecture given at the XXIII International Bile Acid Meeting (Falk Symposium 194) on 'Bile Acids as Signal Integrators and Metabolic Modulators' held in Freiburg, October 8-9, 2014, and summarizes the recent progress with norUDCA as a novel therapeutic approach in cholestatic and metabolic (liver) disorders. 2015 S. Karger AG, Basel.

Find related publications in this database (using NLM MeSH Indexing)

Animals -

Bile Duct Diseases - drug therapy

Humans -

Liver Diseases - drug therapy

Metabolic Diseases - drug therapy

Signal Transduction - drug effects

Ursodeoxycholic Acid - analogs & derivatives

Ursodeoxycholic Acid - therapeutic use

Find related publications in this database (Keywords)

Primary sclerosing cholangitis

Primary biliary cirrhosis

Bicarbonate umbrella

Nonalcoholic fatty liver disease

Atherosclerosis

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