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SHR Neuro Cancer Cardio Lipid Metab Microb

Parwani, AS; von Haehling, S; Kolodziejski, AI; Huemer, M; Wutzler, A; Attanasio, P; Stojakovic, T; Scharnagl, H; Haverkamp, W; Boldt, LH.
Mid-regional proadrenomedullin levels predict recurrence of atrial fibrillation after catheter ablation.
Int J Cardiol. 2015; 180(5):129-133 Doi: 10.1016/j.ijcard.2014.11.117
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Co-authors Med Uni Graz

Scharnagl Hubert

Stojakovic Tatjana

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Abstract:

We evaluated the prognostic value of mid-regional proadrenomedullin (MR-proADM) in atrial fibrillation (AF) patients undergoing radiofrequency ablation. Plasma concentrations of MR-proADM were measured at baseline and after 12months in 87 AF patients in whom radiofrequency ablation was performed. The association between MR-proADM and AF recurrence was tested by univariable and multivariable Cox models. In all 87 patients radiofrequency ablation was successfully performed. Of the total population 54% had paroxysmal AF. The mean left ventricular ejection fraction was 54% (minimum 25%). After 12months of follow-up, 71% of the patients were free of AF recurrence. At baseline, mean MR-proADM in the total population was 0.72nmol/l±0.22. Patients with AF recurrence had significantly higher baseline MR-proADM (0.89nmol/l±0.29) as compared with patients without AF recurrence (0.65nmol/l±0.14; p<0.001). After 12months, mean MR-proADM plasma concentration remained higher in patients with AF recurrence (0.81nmol/l±0.22 as compared with patients free of AF 0.54nmol/l±0.20; p<0.001). Receiver operating characteristic (ROC) curve analysis for MR-proADM yields a specificity of 98% and a sensitivity of 64% with an optimal cut-off value of 0.82nmol/l to predict recurrence of AF after catheter ablation. In the logistic regression analysis only MR-proADM remained independently predictive for AF recurrence. This is the first study revealing the association between MR-proADM elevation before ablation and poor outcomes after ablation of AF. Larger studies are needed to validate these results. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Find related publications in this database (using NLM MeSH Indexing)

Adrenomedullin - blood

Atrial Fibrillation - blood

Atrial Fibrillation - physiopathology

Atrial Fibrillation - surgery

Catheter Ablation -

Female -

Follow-Up Studies -

Humans -

Male -

Middle Aged -

Predictive Value of Tests -

Prognosis -

Prospective Studies -

Protein Precursors - blood

ROC Curve -

Recurrence -

Treatment Outcome -

Find related publications in this database (Keywords)

Cather ablation of atrial fibrillation

Biomarkers

Atrial fibrillation recurrence

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