Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Porpaczy, E; Tauber, S; Bilban, M; Kostner, G; Gruber, M; Eder, S; Heintel, D; Le, T; Fleiss, K; Skrabs, C; Shehata, M; Jager, U; Vanura, K; .
Lipoprotein lipase in chronic lymphocytic leukaemia - Strong biomarker with lack of functional significance.
LEUK RES. 2013; 37(6): 631-636. Doi: 10.1016/j.leukres.2013.02.008 [OPEN ACCESS]
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Co-authors Med Uni Graz

Kostner Gerhard

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Abstract:

In chronic lymphocytic leukaemia (CLL), lipoprotein lipase (LPL) mRNA overexpression is an established poor prognostic marker, its function, however, is poorly understood. Measuring extracellular LPL enzymatic activity and protein, we found no difference between levels in CLL patients and those of controls, both before and after heparin treatment in vivo and in vitro. Investigating LPL knock down effects, we determined five potential downstream targets, of which one gene, STXBP3, reportedly is involved in fatty acid metabolism. While possibly reflecting an epigenetic switch towards an incorrect transcriptional program, LPL overexpression by itself does not appear to significantly influence CLL cell survival.

Find related publications in this database (using NLM MeSH Indexing)

Cell Survival - drug effects Cell Survival - genetics

Cells, Cultured -

Cohort Studies -

Gene Expression Profiling -

Gene Expression Regulation, Leukemic - drug effects

Gene Knockdown Techniques -

HeLa Cells -

Humans -

Leukemia, Lymphocytic, Chronic, B-Cell - blood Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology

Lipoprotein Lipase - antagonists & inhibitors Lipoprotein Lipase - blood Lipoprotein Lipase - genetics Lipoprotein Lipase - physiology

Microarray Analysis -

Predictive Value of Tests -

Prognosis -

RNA, Small Interfering - pharmacology

Retrospective Studies -

Tumor Markers, Biological - blood Tumor Markers, Biological - genetics

Find related publications in this database (Keywords)

CLL

LPL

Functional role

Knock down

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