Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Obrowsky, S; Chandak, PG; Patankar, JV; Povoden, S; Schlager, S; Kershaw, EE; Bogner-Strauss, JG; Hoefler, G; Levak-Frank, S; Kratky, D.
Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling.
J Lipid Res. 2013; 54(2):425-435 Doi: 10.1194/jlr.M031716 [OPEN ACCESS]
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Leading authors Med Uni Graz

Kratky Dagmar

Obrowsky Sascha

Co-authors Med Uni Graz

Chandak Prakash Gopal Das

Höfler Gerald

Levak Sanja

Patankar Jay Vasant

Rainer Silvia

Schlager Stefanie

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Abstract:

Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme mediating triglyceride (TG) hydrolysis. The lack of ATGL results in TG accumulation in multiple tissues, underscoring the critical role of ATGL in maintaining lipid homeostasis. Recent evidence suggests that ATGL affects TG metabolism via activation of peroxisome proliferator-activated receptor α (PPARα). To investigate specific effects of intestinal ATGL on lipid metabolism we generated mice lacking ATGL exclusively in the intestine (ATGLiKO). We found decreased TG hydrolase activity and increased intracellular TG content in ATGLiKO small intestines. Intragastric administration of [(3)H]trioleate resulted in the accumulation of radioactive TG in the intestine, whereas absorption into the systemic circulation was unchanged. Intraperitoneally injected [(3)H]oleate also accumulated within TG in ATGLiKO intestines, indicating that ATGL mobilizes fatty acids from the systemic circulation absorbed by the basolateral side from the blood. Down-regulation of PPARα target genes suggested modulation of cholesterol absorption by intestinal ATGL. Accordingly, ATGL deficiency in the intestine resulted in delayed cholesterol absorption. Importantly, this study provides evidence that ATGL has no impact on intestinal TG absorption but hydrolyzes TGs taken up from the intestinal lumen and systemic circulation. Our data support the role of ATGL in modulating PPARα-dependent processes also in the small intestine.

Find related publications in this database (using NLM MeSH Indexing)

Animals -

Biological Transport -

Cholesterol - metabolism

Down-Regulation -

Fatty Acids, Nonesterified - metabolism

Feces - chemistry

Gene Knockout Techniques -

Homeostasis -

Intestinal Absorption -

Intestine, Small - cytology

Lipase - deficiency

Male -

Mice -

Organ Specificity -

PPAR alpha - metabolism

Signal Transduction -

Triglycerides - blood

Find related publications in this database (Keywords)

triglyceride absorption

cholesterol absorption

enterocytes

peroxisome proliferator-activated receptor alpha target genes

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