Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Pabst, G; Zweytick, D; Prassl, R; Lohner, K.
Use of X-ray scattering to aid the design and delivery of membrane-active drugs
Eur Biophys J. 2012; 41(10):915-929 Doi: 10.1007/s00249-012-0821-9
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Co-authors Med Uni Graz

Prassl Ruth

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Abstract:

Biological membranes can be targets for compounds that either disrupt their barrier function or affect protein function via membrane-mediated processes. Biophysical studies on membrane-mimetic systems composed of membrane lipids have contributed substantially to our knowledge on the pertaining membrane physics and aid the development of membrane-specific drugs. Moreover, lipid membranes and, in particular, liposomes are convenient systems for drug delivery. We review some of our recent work that demonstrates the applicability of X-ray scattering to understanding the molecular mechanisms of drug-membrane interactions. In particular we focus on effects of anesthetics, sphingomyelinase, and antimicrobial peptides. We further discuss X-ray scattering as a quality-control tool for liposomal drug-delivery systems.

Find related publications in this database (using NLM MeSH Indexing)

Animals -

Cell Membrane - chemistry

Drug Design -

Humans -

Lipid Bilayers - chemistry

Liposomes - chemistry

Membrane Proteins - chemistry

X-Ray Diffraction -

Find related publications in this database (Keywords)

Lipid bilayer

Non-lamellar phases

Micelles

Liposomes

Lipid-drug interactions

Lipid-protein interactions

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