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SHR Neuro Cancer Cardio Lipid Metab Microb

Bondarenko, OI; Sahach, VF.
Role of mitochondria in reglulation of endothelial cell hyperpolarization to acetylcholine.
Fiziol Zh. 2006; 52(5):6-11
PubMed

Leading authors Med Uni Graz: Bondarenko Oleksandr
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Abstract:: We investigated the regulation of sustained endothelial hyperpolarization to acetylcholine in the rat aortic endothelial cells by mitochondria. Protonofore CCCP and rotenone, an electron transport chain complex I inhibitor, agents that cause mitochondria depolarization, inhibited the sustained hyperpolarization of endothelial cells. This effect was unlikely to be mediated by the free radicals since hydrogen peroxide was shown to hyperpolarize endothelial cells. It is concluded that mitochondrial Ca2+ uptake is essential in prolongation of endothelial hyperpolarization to acetylcholine.
Find related publications in this database (using NLM MeSH Indexing): Acetylcholine - pharmacology; Animals -; Aorta, Thoracic - cytology Aorta, Thoracic - drug effects; Calcium - metabolism; Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology; Endothelial Cells - cytology Endothelial Cells - drug effects; Endothelium, Vascular - cytology Endothelium, Vascular - drug effects; Ionophores - pharmacology; Membrane Potentials - drug effects; Mitochondria - physiology; Rats -; Rotenone - pharmacology