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Bodlaj, G; Hubmann, R; Saleh, K; Stojakovic, T; Biesenbach, G; Berg, J.
Alkaline phosphatase predicts relapse in chronic hepatitis C patients with end-of-treatment response.
World J Gastroenterol. 2010; 16(19): 2407-2410. Doi: 10.3748/wjg.v16.i19.2407 [OPEN ACCESS]
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Co-authors Med Uni Graz

Berg Jörg

Stojakovic Tatjana

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Abstract:

AIM: To investigate relapse predictors in chronic hepatitis C (CHC) patients with end-of-treatment response (ETR), after pegylated interferon-alpha (PegIFN-alpha) and ribavirin treatment. METHODS: In a retrospective study we evaluated a spectrum of predictors of relapse after PegIFN-alpha and ribavirin treatment in 86 CHC patients with ETR. Viral loads were determined with real-time reverse transcription polymerase chain reaction. Hepatitis C virus genotyping was performed by sequencing analysis. Patients with genotype 1 were treated for 48 wk with 180 microg PegIFN-alpha2a or 1.5 microg/kg PegIFN-alpha2b once weekly plus ribavirin at a dosage of 1000 mg/d for those under 75 kg or 1200 mg/d for those over 75 kg. Patients with genotypes 2 and 3 were treated for 24 wk with 180 microg PegIFN-alpha2a or 1.5 microg/kg PegIFN-alpha2b once weekly plus ribavirin at a dosage of 800 mg/d. RESULTS: In all ETR patients, binary logistic regression analysis identified absence of complete early virological response (cEVR) (OR 27.07, 95% CI: 3.09-237.26, P < 0.005), serum alkaline phosphatase (ALP) levels prior to therapy < 75 U/L (OR: 6.16, 95% CI: 2.1-18.03, P < 0.001) and body mass index > 26 kg/m(2) (OR: 8.27, 95% CI: 2.22-30.84, P < 0.005) as independent predictors of relapse. When cEVR patients were analyzed exclusively, ALP prior to therapy < 75 U/L remained the only predictor of relapse. CONCLUSION: Lower levels of ALP prior to, during and after therapy seem to be associated with a higher risk of relapse in CHC patients with ETR.

Find related publications in this database (using NLM MeSH Indexing)

Adolescent -

Adult -

Aged -

Alkaline Phosphatase - blood

Antiviral Agents - therapeutic use

Biological Markers - blood

Drug Therapy, Combination -

Female -

Genotype -

Hepacivirus - genetics

Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - enzymology

Humans -

Interferon-alpha - therapeutic use

Logistic Models -

Male -

Middle Aged -

Odds Ratio -

Polyethylene Glycols - therapeutic use

Predictive Value of Tests -

RNA, Viral - blood

Recombinant Proteins -

Recurrence -

Retrospective Studies -

Ribavirin - therapeutic use

Risk Assessment -

Risk Factors -

Time Factors -

Treatment Outcome -

Viral Load -

Young Adult -

Find related publications in this database (Keywords)

Alkaline phosphatase

Chronic hepatitis C

Pegylated interferon

Predictor

Relapse

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