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Köttgen, A; Pattaro, C; Böger, CA; Fuchsberger, C; Olden, M; Glazer, NL; Parsa, A; Gao, X; Yang, Q; Smith, AV; O'Connell, JR; Li, M; Schmidt, H; Tanaka, T; Isaacs, A; Ketkar, S; Hwang, SJ; Johnson, AD; Dehghan, A; Teumer, A; Paré, G; Atkinson, EJ; Zeller, T; Lohman, K; Cornelis, MC; Probst-Hensch, NM; Kronenberg, F; Tönjes, A; Hayward, C; Aspelund, T; Eiriksdottir, G; Launer, LJ; Harris, TB; Rampersaud, E; Mitchell, BD; Arking, DE; Boerwinkle, E; Struchalin, M; Cavalieri, M; Singleton, A; Giallauria, F; Metter, J; de Boer, IH; Haritunians, T; Lumley, T; Siscovick, D; Psaty, BM; Zillikens, MC; Oostra, BA; Feitosa, M; Province, M; de Andrade, M; Turner, ST; Schillert, A; Ziegler, A; Wild, PS; Schnabel, RB; Wilde, S; Munzel, TF; Leak, TS; Illig, T; Klopp, N; Meisinger, C; Wichmann, HE; Koenig, W; Zgaga, L; Zemunik, T; Kolcic, I; Minelli, C; Hu, FB; Johansson, A; Igl, W; Zaboli, G; Wild, SH; Wright, AF; Campbell, H; Ellinghaus, D; Schreiber, S; Aulchenko, YS; Felix, JF; Rivadeneira, F; Uitterlinden, AG; Hofman, A; Imboden, M; Nitsch, D; Brandstätter, A; Kollerits, B; Kedenko, L; Mägi, R; Stumvoll, M; Kovacs, P; Boban, M; Campbell, S; Endlich, K; Völzke, H; Kroemer, HK; Nauck, M; Völker, U; Polasek, O; Vitart, V; Badola, S; Parker, AN; Ridker, PM; Kardia, SL; Blankenberg, S; Liu, Y; Curhan, GC; Franke, A; Rochat, T; Paulweber, B; Prokopenko, I; Wang, W; Gudnason, V; Shuldiner, AR; Coresh, J; Schmidt, R; Ferrucci, L; Shlipak, MG; van Duijn, CM; Borecki, I; Krämer, BK; Rudan, I; Gyllensten, U; Wilson, JF; Witteman, JC; Pramstaller, PP; Rettig, R; Hastie, N; Chasman, DI; Kao, WH; Heid, IM; Fox, CS.
New loci associated with kidney function and chronic kidney disease.
Nat Genet. 2010; 42(5): 376-384. Doi: 10.1038/ng.568 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz

Cavalieri Margherita

Schmidt Helena

Schmidt Reinhold

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Abstract:

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

Find related publications in this database (using NLM MeSH Indexing)

Cohort Studies -

Creatinine - blood

Cystatin C - genetics

Diet -

Europe -

Genetic Markers - genetics

Genome-Wide Association Study -

Glomerular Filtration Rate -

Humans -

Kidney - physiology

Kidney Failure, Chronic - ethnology Kidney Failure, Chronic - genetics

Models, Genetic -

Risk Factors -

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