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PREGENESYS: Development of Early Non-Invasive Biomarkers and Means for the Diagnosis and Progression Monitoring of Preeclampsia and Tailoring Putative Therapies

Abstract

Preeclampsia (PET), de-novo hypertension & proteinuria after mid gestation, affects 5-7% of all pregnancies. Cases may develop life threatening haemolysis-elevated liver enzymes-low platelets (HELLP) or renal failure, cerebral haemorrhages & eclampsia, IUGR, placental abruption & death.
We will identify markers for PET risk prediction in the 1st trimester to allow longer time for tailoring putative medications to prevent PET, and assess & characterize plausible links between marker shortage/access, PET & putative medications in "in-vitro" systems to fit putative medications to pre-defined disease-risk women.
We will develop non-invasive diagnostic kits for 1st trimester PET prediction based on markers, antibodies, oligos & siRNA and others coupled to the power of Doppler ultrasound. Nested case-control clinical studies will test effectiveness of combined diagnosis & drug tailoring. A Trans European prospective clinical study, combining early diagnosis & randomising putative medication will verify findings.
R&D results will be used to train physicians & patients, to implement new prenatal care practice and eradicate preeclampsia.

Local Subprojectlead:

Huppertz Berthold

Duration:

01.12.2006-30.11.2009

Programme:

EU (FP-6)

Subprogramme

Biowissenschaften

EU-Project Instruments

Spec. Target. o Inn. Project (STREP)

Type of Research

basic research

Staff

Huppertz, Berthold, Project Leader

Scheiber, Beate, Co-worker

MUG Research Units

Division of Cell Biology, Histology and Embryology

Project partners

Barking, Havering & Redbridge Hospitals NHS Trust, United Kingdom
Contact person: Prof. Kevin Spencer;

Diagnostic Technologies, Israel
Contact person: Dr. Hamutal Meiri;

Fetal Medicine Foundation, United Kingdom
Contact person: Prof. Kypros H Nicolaides;

Global Research & Financing, Israel
Contact person: Prof. Zohar Ben-Asher;

ImmunoSTAR, Portugal
Contact person: Pedro Seada;

Semmelweis University Budapest, Hungary
Contact person: Dr. Nandor Gabor Than;

University of Basel, Switzerland
Contact person: Prof. Sinuhe Hahn;

University of Milan, Italy
Contact person: Prof. Irene Cetin;

Wallac, Finland
Contact person: Yvonne Parker;

Funded by

Europäische Kommission, Rue de la Loi, Brussels, Belgium

Project results published

> Development of early non-invasive markers and mean... PLACENTA. 2011; 32: S1-S3.

> Pregenesys pre-eclampsia markers consensus meeting... PLACENTA. 2011; 32: S4-S16.

> Placenta-bound and Body Fluid PP13 and its mRNA in... PLACENTA. 2011; 32: S30-S36.

> Placental and trophoblastic in vitro models to stu... PLACENTA. 2011; 32: S49-S54.

> Cryogenic and low temperature preservation of huma... PLACENTA. 2011; 32: S65-S76.

> Effects of calcium, magnesium, low-dose aspirin an... PLACENTA. 2011; 32: S55-S64.